Ajinomoto Co., Ltd.

Juridical Foundation, Japanese Foundation for Cancer Research

Teijin Limited

Japanese Foundation for Cancer Research

Masami Muramatsu

Tadatsugu Taniguchi

Haruo Sugano

Hiroshi Matsui

Nobukazu Kashima

Junji Hamuro

Yataro Ichikawa

Yoshihiko Sumi

Nobuo Aoki

Disclosed is a recombinant plasmid having a gene which encompasses at least the entire coding region of human fibroblast interferon messenger RNA and a method for preparing such plasmid.

DNA and recombinant plasmid

A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is trans-formed to produce interleukin-2.

Gene coded for interleukin-2 polypeptide, recombinant DNA carrying the

A gene coded for a polypeptide which possesses interleukin-2 is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.

Gene encoding interleukin-2 polypeptide, recombinant DNA carrying the

Recombinant human Interleukin-2 (IL-2) polypeptides are provided. The polypeptides are produced by expression of suitable nucleic acid molecules in transformed host cells such as E. coli.

Unglycosylated human interleukin-2 polypeptides

A protein having human plasmin inhibiting activity, substantially equivalent reactivity with human plasmin to a human .alpha..sub.2 -plasmin inhibitor derived from plasma, a binding ability to human fibrin about 1/4 to about 1/3 of that of the human .alpha..sub.2 -plasmin inhibitor derived from plasma, and a molecular weight of about 50,000 to about 77,000.

Protein having human plasmin inhibiting activity

A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.

Growing community of inventors

Tokorozawa, Japan

Masami Muramatsu