Ss Pharmaceutical Co., Ltd.

Masami Moroi

Toshio Yokoyama

Akira Iwasa

Kimie Ominato

Compositions suitable for use in the preparation of dosage-form active vitamins D.sub.3 are disclosed. Each composition comprises an active vitamin D.sub.3 and a stabilizer selected from polyvinylacetal diethylaminoacetate and hydroxypropylcellulose. Also disclosed are processes for the preparation of stable dosage-form active vitamins D.sub.3. Each process comprises adding the above stabilizer to an active vitamin D.sub.3 and then adding a pharmaceutically-acceptable carrier to the resultant mixture.

Composition for the preparation of dosage-form active vitamins D.sub.3

A composition for foaming preparation comprising (a) an organic acid of which the crystal surface is coated with a sugar and (b) a carbonate is disclosed. In the composition, an organic acid is completely shut off from a carbonate by a sugar coating so that the acid does not react with the carbonate over a prolonged storage time. When the composition is put into mouth, the sugar which covers the acid is readily dissolved, allowing the acid and the carbonate to react and to generate carbon oxide gas. An excellent foaming calcium preparation can be produced by using calcium carbonate as the carbonate or by adding other salt of calcium to the composition. Such a calcium preparation gives a good taste and favorable feeling upon administration. It is especially suitable for regular administration of calcium over an extended period of time.

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Yachiyo, Japan

Masami Moroi