Mitsui Sugar Co., Ltd.

Japan Science and Technology Agency

The Kitasato Institute

Fukuoka Prefectural Government

Mizu, Masami

Masami Mizu

Seiji Shinkai

Kazuo Sakurai

Toma Furuta

Kazuya Koumoto

Kiyoaki Miyasaka

Munenori Numata

Satoshi Omura

Haruki Yamada

Jun Kashimura

Toshikazu Kawai

Masato Iwatsuki

Kazuhiko Otoguro

Kenji Koge

Takahiro Matsumoto

Taro Kimura

Hiroaki Kiyohara

Aki Ishiyama

Tomohisa Fujisawa

Teruaki Hasegawa

Kazuyo Shiomi

Miki Sakazaki

Satoru Itou

Sayoko Fujii

One aspect of the present invention provides an anti-obesity agent, an anti-dementia agent, a deodorant, an anti-aging agent, an anti-glycation agent, an anti-type I allergy agent, a hypotensive agent, a flavor improving agent, a muscle enhancing agent, and a bone metabolism improving agent which contain a bagasse decomposition extract as an active ingredient.

Anti-obesity agent, anti-dementia agent, deodorant, anti-aging agent, anti-glycation agent, anti-type I allergy agent, hypotensive agent, flavor improving agent, muscle enhancing agent, and bone metabolism improving agent

The present invention provides a Peyer's patch activator containing a polysaccharide obtained from sugar cane as an active ingredient, wherein the polysaccharide contains &#x3b1;-glucan as a main component and has a peak molecular weight within a range of 720,000 to 1,080,000, with a proportion of glucose in all component sugars being 80% or more, and proportions of nonreducing terminal glucose and &#x3b1;-1,6-linked glucose being 20 to 30% and 15 to 25%, respectively.

Peyer's patch activator

Disclosed is a complex which comprises a carbon nanotube and a modified polysaccharide having a backbone chain with the side thereof being introduced with monosaccharide or oligosaccharide residues. The polysaccharide is preferably &#x3b2;-1,3-glucan. The complex is prepared by admixing a solution of the modified polysaccharide dissolved in an aprotic polar solvent or a strong alkali solution with an aqueous dispersion of the carbon nanotube, and incubating the mixture.

Polysaccharide-carbon nanotube complex

Disclosed is a new type of immunostimulating agent including an immunostimulating oligonucleotide complexed with a carrier which is safe and has a high transfection effect. The carrier complexed with the immunostimulating oligonucleotide to form the immunostimulating agent is a polysaccharide having &#x3b2;-1,3-bonds (preferably &#x3b2;-1,3-glucan such as schizophyllan). A preferred example of the immunostimulating oligonucleotide is one containing an unmethylated CpG motif. The polysaccharide for use is preferably modified with nucleic acid-binding functional group and/or cell membrane-affinitive functional group.

Immunostimulating agents

Disclosed are gene carriers utilizing &#x3b2;-1,3-glucan and methods of preparing the same. The &#x3b2;-1,3-glucan has at least one 1,6-glucopyranoside branch and is chemically modified through periodate oxidation and reductive amination so as to impart nucleic acid-binding functional groups (for example, cationic functional groups) to at least some of the 1,6-glucopyranoside branches thereof. Triple helix &#x3b2;-1,3-glucan is dissolved in a polar organic solvent to form single-stranded &#x3b2;-1,3-glucan. By replacing, in the presence of a nucleic acid, the polar organic solvent for the solution containing the chemically modified single-stranded &#x3b2;-1,3-glucan by water, a complex (gene carrier) is formed in which the nucleic acid is bound to double-stranded &#x3b2;-1,3-glucan.

Gene carriers with the use of polysaccharide and process for producing the same

Growing community of inventors

Sakai, Japan

Masami Mizu