Mitsui Toatsu Chemicals, Incorporated

Masami Imadegawa

Hideki Kawashima

Tadashi Suzuki

Kenichi Ishiwata

Nobuyoshi Makiguichi

This invention is a method of producing L-serine by causing glycine to react with formaldehyde by using the culture solution or the microbe cells of a microorganism belonging to the genus Escherichia, having the ability of producing serine hydroxymethyltransferase and not having the practical ability of producing L-serine from glycine alone or enzymatic matter obtained through the treatment of the above culture solution or microbe cells. In this invention, the yield of L-serine can be increased either by carrying out the reaction while maintaining aldehyde concentration at 20 mM or below or by using microbe cells of the aforementioned microorganism after they are caused to contact glycine.

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Kanagawa, Japan

Masami Imadegawa