Nb Health Laboratory Co., Ltd.

Masami Ashida

Kiyoshi Takayama

Yuji Urushibata

To provide a technique for selecting a target cell producing a target substance that specifically binds to a desired cell membrane protein more rapidly and efficiently. A substratehaving a plurality of microwellsis provided. A first cellexpressing a target cell membrane protein on its surface is allowed to adhere to each of the microwells. One or two second cellsas a candidate of a target cell are introduced into each microwell, and are allowed to coexist with the first cellin the microwell, and target substancesecreted by the second cellis brought into contact with the first cell. A microwellincluding the first cellto which the target substancebinds is identified. The second cellas the target cell is recovered from the identified microwell. One example of the target substanceis an antibody. Visualization may be performed by adding a label substance

Method for selecting cells, method for producing nucleic acid, method for producing recombinant cells, method for producing target substance, method for producing pharmaceutical composition, and reagent

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Sapporo, Japan

Masami Ashida