Fujisawa Pharmaceutical Company, Ltd.

Masakuni Okuhara

Hiroshi Hatanaka

Hirokazu Tanaka

Toshio Goto

Shigehiro Takase

Tohru Kino

Nobuharu Shigematsu

Masami Ezaki

Masanori Okamoto

Eisaku Tsujii

Yasuhisa Tsurumi

Seiji Hashimoto

Sumio Kiyoto

Akihiko Fujie

Satoshi Okada

Motoaki Nishikawa

Kumiko Nitta

Masashi Hashimoto

Hiroshi Imanaka

Michio Yamashita

Hatsuo Aoki

Chiyoshi Kasahara

Yasuhiro Hori

Hiroshi Terano

Motohiro Hino

Hidetsugu Murai

Toshiro Iwamoto

Hidenori Nakajima

Michiyo Miyauchi

Takanao Otsuka

Tomoko Sato

Takashi Fujita

Teruo Kyoto Oku

Kazuo Sakane

Keiji Hemmi

Kohji Kawabata

Masanobu Kohsaka

Kozo Sawada

Hidenori Ohki

Itsuo Uchida

Eiko Iguchi

Yoshio Kuroda

Naoki Fukami

Miho Tanaka

Nobutaka Oohata

Hideo Hirai

Eiko Kino

Tsutomu Kaizu

Akira Katayama

Keiji Hemmi, Deceased

Kunio Nakahara

Toru Kino

Toshihiro Shibata

Seiji Yoshimura

Yoshitada Notsu

Yasuhiko Shinguh

Noriaki Inamura

Koen Verhaeghe

Hirotsugu Ueda

Method for inhibiting interleukin-2 production using tricyclo compounds

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula:

Method for inhibiting lymphokine production

Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.

Method of immunosuppression

Process for production of tricyclo compounds with streptomyces

Strain of Streptomyces for the production of tricyclo compounds

Tricyclo compounds, a process for their production and a pharmaceutical

The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.

WF11243 substance

WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations

WB2663 substances and method for their production

A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.

Antimicrobial agent, FR109615 and production thereof

A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.

Antimicrobial polypeptide compound a pharmaceutical composition

Production of cyclosporin A and/or C with a strain of NECTRIA

The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.

Process for producing WS-9326A and WS-9326B

Growing community of inventors

Tsukuba, Japan

Masakuni Okuhara