The Noguchi Institute

Immuno-Biological Laboratories Co., Ltd.

Masako Mori

Takashi Shirai

Jun Nakayama

Masaya Fujita

Masahiro Tomita

Takashi Yamanoi

Masaki Kurogochi

The present invention is aimed to provide a method for preparing an acceptor that is N-glycan hydrolyzed antibody or a Fc fragment thereof used for producing antibody having a homogeneous N-glycan structure; a method for determining a combination of endoglycosidases for use in said preparation; and a method for measuring N-glycans linked to an antibody. The present invention is directed to a method for producing a N-glycan hydrolyzed antibody or Fc fragment thereof, comprising reacting the antibody or the Fc fragment thereof with several endoglycosidases; and a method for determining quantitative information of an objective N-glycan with a desired structure linked to an antibody or a Fc thereof, comprising a protease treatment step and a glycopeptide measurement step, etc.

Method for preparing glycan-hydrolyzed antibody, and homogeneous glycosylated antibody

A method for directly inhibiting proliferation ofbacteria, that includes administering to a subject infected withan N-acetylglucosaminyl beta-linked monosaccharide represented by:GlcNAcl-beta-O&#x2014;Ywhere Y is an alkyl group, an alkoxyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, a heteroaryl group, a carboxyl group, or an alkoxycarbonyl group.

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Tokyo, Japan

Masako Mori