Fujisawa Pharmaceutical Company, Ltd.

Masako Kuno

Kiyoshi Tsuji

Katsuya Nakamura

Tadashi Terasaka

Hiroyuki Okumura

Susumu Tsujimoto

Nobuo Seki

Takayoshi Kinoshita

Isao Nakanishi

Nobuya Nishio

Akihiro Sato

Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R is hydrogen or lower alkyl; R is hydroxy or protected hydroxy; R is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and &mdash;A&mdash; is &mdash;Q&mdash; or &mdash;O&mdash;Q&mdash;, wherein Q is single bond or lower alkylene, provided that when R is lower alkyl, then R is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.

Imidazole compounds

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Amagasaki, Japan

Masako Kuno