Pfizer Corporation

Masako Hirota

Hiroki Koike

Sachiko Mihara

Yoshinobu Hashizume

Yukari Matsumoto

Hiroshi Nakamura

Hisoshi Nakamura

This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein Rand Rindependently represent a hydrogen atom or the like; Rrepresents a hydrogen atom, or the like; Rrepresents a hydrogen atom or the like; represents one of the following or the like; Rrepresents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists

This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein Rand Rindependently represent a hydrogen atom or the like; These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists

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Aichi-ken, Japan

Masako Hirota