Nippon Chemiphar Co., Ltd.

Fujirebio Kabushiki Kaisha

Masaki Uehara

Yoshiaki Sato

Mitsuo Masaki

Yoshikazu Isowa

Yoshiharu Nakashima

Kenji Hirate

Norihisa Miyake

Seiji Kondo

Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Hat or Cit;

Peptides, and antidementia agents containing the same

A novel peptide derivative having the formula: ##STR1## wherein A between Pro and Q.sup.2 is Arg or Lys: Q.sup.1 is pGlu or H; Q.sup.2 is --Gly--OH or OH; Y.sup.1 is H or --CO--T and Y.sup.2 is OH or T; wherein T is a thiamine derivative group is disclosed. The peptide derivative shows a remarkable nootropic effect.

Peptide derivatives and antidemetia agents

A peptide having one of the following formulae (I), (II), (III) and (IV): ##STR1## or its functional derivatives, and a pharmaceutically acceptable salt thereof are disclosed. These peptides have a nootropic effect and are effective as antidementia agents.

Petide antidementia and nootropic agents

Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Har or Cit;

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Saitama, Japan

Masaki Uehara