Fujisawa Pharmaceutical Company, Ltd.

Masaki Tomishima

Akira Yamada

Hisashi Takasugi

Hidenori Ohki

Hiroshi Miyake

Kazuhiko Take

Kiyotaka Ito

Fumie Takahashi

Glen W Spears

Amide compounds

Cyclohexapeptides having antimicrobial activity

A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.

Pyridine compounds and their pharmaceutical use

This invention relates to new polypeptide compounds represented by the following formula (I):

Cyclic hexapeptides having antibiotic activity

A process for preparing a polypeptide compound having antimicrobial activities of the following general formula: ##STR1## wherein R.sup.1 is hydrogen

Polypeptide compound and a process for preparation thereof

A polypeptide compound having antifungal activities of the following general formula: ##STR1## wherein R.sup.1 is hydrogen R.sup.2 is acyl group,

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Osaka, Japan

Masaki Tomishima