Kissei Pharmaceutical Co., Ltd.

Masaki Tomae

Masayuki Isaji

Nobuhiko Fushimi

Kazuo Shimizu

Shigeru Yonekubo

Hirotaka Teranishi

The present invention provides pyrazole derivatives represented by the general formula: wherein Rrepresents H, an optionally substituted Calkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted Calkyl group etc.; Rrepresents H, a halogen atom, OH, an optionally substituted Calkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted Calkylene group etc.; Z represents &#x2014;R, &#x2014;CORetc. in which Rrepresents an optionally substituted Calkyl group etc.; and Rrepresents an optionally substituted Calkyl group etc.; Rrepresents H, an optionally substituted Calkyl group etc.; and R, Rand Rrepresent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

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Nagano, Japan

Masaki Tomae