Meiji Co., Ltd.

Meiji Dairies Corporation

Masaki Terahara

Yoshitaka Nakamura

Makoto Yamaguchi

Hiroyuki Itou

Takeshi Takahashi

Takashi Iwase

Shuji Ikegami

Katsunori Kimura

Kiyoshi Yamada

Shinya Nagafuchi

Seiko Narushima

Masako Yajima

Toshihiro Sashihara

Mamoru Totsuka

Satsuki Totsu

Satoshi Kusuda

Itaru Moro

Kuniyasu Ochiai

Itaruv Moro

An object of the present invention is to provide a brain function improving agent for neonates, especially, newborn neonates. According to the present invention, there is provided a brain function improving agent for neonates, comprising a lactic acid bacterium and/or a. The brain function improving agent or composition for improving brain function for neonates according to the present invention is advantageous in that the use thereof can improve the developmental quotient without any side effect and also enables effective development and growth of neonates.

Composition for improving brain function for neonates

The present invention provides a novel anticariogenic agent without side effects so that anticariogenic effect can also be obtained in humans who are highly sensitive to oligosaccharides and sugar alcohols. Also, an agent for preventing periodontal disease or for treating periodontal disease which has an effect of preventing or treating periodontal disease and which does not have side effects is provided. The invention relates to an anticariogenic agent and an anticariogenic composition comprising a bifidobacterium, an agent and a composition for preventing periodontal disease comprising a bifidobacterium and an agent and a composition for treating periodontal disease comprising a bifidobacterium.

Anticariogenic agent and anticariogenic composition

A probioticwas discovered from lactobacilli of thegenus independently isolated from human adult feces. The probioticwas selected from other bacterial strains for: (1) being highly resistant to gastric acid/bile acid; (2) having a high promoting activity on IL-12 production from mouse derived spleen cells and a high Th1/Th2 balance-improving effect; (3) having a high ability to inhibit the production of antigen-specific IgE induced by intraperitoneally administering ovalbumin to BALB/c mice; (4) having a high ability to inhibit the production of antigen-specific IgE induced by orally administering a food antigen to C57BL/6N mice; (5) having a high Natural Killer cell-activating ability; (6) having a high IL-12 production-promoting activity on spleen cells and mesenteric lymph node cells derived from mice immunized with ovalbumin and a high Th1/Th2 balance-improving effect; and (7) having a high ability to suppress eosinophilia induced by a cedar pollen-extracted antigen. This discovery led to the completion of the present invention.

Immune function modulating agents

The present invention relates to a composition for immunostimulation useful for promoting IgA and secretory component productions in mucosal tissues, comprising, alone or in combination, a cell ofbelonging toor a processed product thereof, wherein thehas an activity to stimulate secretory component production and a high activity to stimulate IgA production, for example, it is aOLB 6377 strain orOLB 6378 strain.

Composition for immunostimulation

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Kanagawa, Japan

Masaki Terahara