Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Masaki Setoh

Shigenori Ohkawa

Masahiro Okura

Yasuyoshi Arikawa

Kouki Kato

Zen-ichi Terashita

Mitsuru Kakihana

Compounds represented by the formula: wherein Rand Rare hydrogen atom, a hydrocarbon group or a heterocyclic group, or Rand Rmay form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates a group represented by the formula: wherein Rindicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, Ris hydrogen atom, a Calkyl, or an acyl group, Rindicates a Caryl group, or salts thereof. The compounds have an excellent action to inhibit neurodegeneration as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as drugs for nerve degenerative diseases.

Benzofuran derivatives, their production and use

Compounds represented by the formula:wherein Rand Rare hydrogen atom, a hydrocarbon group or a heterocyclic group, or Rand Rmay form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates

A compound of the formula:wherein Rand Reach is H or a hydrocarbon group which may be substituted, or Rand Rform a 3- to 8-membered carbo or heterocyclic ring which may be substituted; Ris H, a lower alkyl which may be substituted or an aromatic group which may be substituted; Ris (1) an aromatic group which may be substituted, (2) an aliphatic hydrocarbon group substituted by an aromatic group which may be substituted, which hydrocarbon group may be further substituted or (3) an acyl; X and Y each is oxygen or sulfur which may be oxidized; and ring A is a benzene ring which may be further substituted, or a salt thereof, is useful for an agent for suppressing neurodegeneration.

Benzofurans as suppressors of neurodegeneration

Benzofuran derivatives, process for the preparation of the same and uses thereof

Tricyclic compound, their production and use

Tricyclic compounds, their production and use

Growing community of inventors

Suita, Japan

Masaki Setoh