Kabushiki Kaisha Yakult Honsha

Masaki Serata

Satoshi Matsumoto

Hirokazu Tsuji

Koichiro Sonoike

Fumiyasu Ishikawa

Tomoyuki Sako

Mayumi Kiwaki

Tohru Iino

Yasuhisa Shimakawa

Mika Miura

Emi Yasuda

Kan Shida

Akimitsu Takagi

Provided is a gene that is useful for imparting hydrogen peroxide resistance to a microorganism. Also provided is a method for using the same. The hydrogen peroxide resistance-imparting gene encoding a protein selected from the following proteins (a) to (c): (a) a protein having the amino acid sequence of SEQ ID NO: 2; (b) a protein which has an amino acid sequence equivalent to the amino acid sequence of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits hydrogen peroxide resistance-imparting activity; and (c) a protein which has an amino acid sequence having an identity of 85% or higher to the amino acid sequence of (a), and which exhibits hydrogen peroxide resistance-imparting activity.

Hydrogen peroxide resistance-imparting gene and method for using same

The invention provides a gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having any of the amino acid sequences of SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, and 108; (b) a protein which has an amino acid sequence equivalent to any of the amino acid sequences of (a), except that one to several amino acid residues are deleted, substituted, or added, and which exhibits cytokine production regulatory activity; and (c) a protein which has an amino acid sequence having 90% or higher identity to any of the amino acid sequences of (a), and which exhibits cytokine production regulatory activity, as well as a gene useful for regulating cytokine production and use of the gene.

Cytokine production regulator gene and use thereof

The present invention provides a bacterium belonging to the genus, which can exhibit a high viability in the storage under agitation and can produce a fermented food containing a large number of viable bacterial count. The present invention further provides a fermented food, which contains the bacterium belonging to the genusand exhibits various physiological effects such as inhibitory action against harmful intestinal bacteria and intestinal function controlling effects. The present invention further provides a bacterium belonging to the genushaving a rate of viability of 30% or more, when the bacterium is stored in the aerobic condition under agitation at 10&#xb0; C. for 14 days after culturing in a medium containing milk as a main ingredient until obtaining a viable count of 1&#xd7;10cfu/ml or more, and fermented food using the same.

[object Object]

Athat is resistant to acid and bile and which retains at least 20% viability after acid and bile treatment. Foods and drinks containing an acid- and bile-resistant. Methods for providing viableto the intestine after ingestion of a food or drink containing an acid- and bile-resistant

Method of evaluating the extent of reaching the intestine of bifidobacterium in fermented milk food or drink

Growing community of inventors

Tokyo, Japan

Masaki Serata