Fujitsu Corporation

Takeda Chemical Industries, Inc.

Teikoku Hormone Mfg. Co., Ltd.

Advance Co., Ltd.

Masaki Itoh

Katsumi Iga

Keiichiro Okabe

Shigeo Yanai

Junichi Koike

Yoshishige Tanaka

A calcitonin, its derivative or a salt thereof is transdermally delivered by iontophoresis in which a substantially constant voltage in the range of 3 to 20 V is applied at an electric current of 0.05 to 0.5 mA/cm.sup.2. In this process, the calcitonin can be delivered transdermally with a higher absorptivity by applying a higher voltage for a short period (at a voltage of about 6 to 14 V for about 5 to 15 minutes) in the initial stage of the voltage application, and then applying a lower voltage for a long period (at a voltage of about 3 to 9 V for about 30 to 40 minutes).

Transdermal drug delivery process

A line circuit for driving a ringer and a service indicating lamp in a telephone set, including a high frequency transformer (T.sub.2), a switching circuit (22) for intermittently disconnecting a D.C. voltage applied to the primary winding of the transformer (T.sub.2), and a control signal generating circuit (23). The control signal generating circuit generates a first control signal having high frequency and having a first duty ratio when the ringer is to be rung; and generates a second control signal having the same frequency but having a second duty ratio smaller than the first duty ratio when the service indicating lamp is to be lit. The first or the second control signal is applied to the switching circuit so that the high frequency transformer generates a ringing signal or a D.C. voltage to light the lamp. Since the high-frequency transformer is commonly used for generating the ringing signal and the D.C. voltage for the lamp, the line circuit can be made small and light.

Line circuit for driving a ringer and a service indicating lamp in a

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Yokohama, Japan

Masaki Itoh