Sysmex Corporation

Masaki Ishisaka

Masakazu Fukuda

Kazuki Kishi

Yasuyuki Imura

Hideo Kusuzawa

Seiichiro Tabata

Hironori Kobayashi

Kenji Akama

Masatoshi Yanagida

Kanako Nagaoka

Yoshinobu Miura

Hideo Kususawa

A particle imaging apparatus comprises a flow path comprising a first flow path section, a second flow path section connected downstream of the first flow path section, and a third flow path section that is branched from the first flow path section, a particle detection unit comprising a light source and a light detector, a particle sorting unit configured to adjust a flow direction of the particle, and a particle imaging unit configured to take an image of a particle that flows in the second flow path section. The flow path is structured such that a cross-sectional area of the second flow path section is greater than a cross-sectional area of the first flow path section. The first flow path section and the second flow path section are disposed so as to be linearly aligned.

Particle imaging apparatus and particle imaging method

A cell analysis apparatus includes an optical detection section that accommodates a flow of a measurement sample obtained from a biological sample and a pigment into a flow cell. A light source irradiates the measurement sample flowing in the flow cell and a fluorescence detector detects fluorescence from the measurement sample. A signal processing circuit acquires a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal, and a system control section distinguishes between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value of the fluorescence signal obtained by the signal processing circuit.

Cell analysis apparatus and cell analysis method

A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided. The cell analysis apparatus () includes: an optical detection section () for flowing a measurement sample obtained from a biological sample and a pigment into a flow cell (), irradiating the measurement sample flowing in the flow cell () with laser beam and detecting fluorescence from the measurement sample; a signal processing circuit () for acquiring, based on a fluorescence signal outputted from the detection section (), a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal; and a system control section () for distinguishing between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value reflecting the height of the waveform of the fluorescence signal and the value reflecting the length of the ridge line of the waveform of the fluorescence signal obtained by the signal processing circuit ().

A sample preparation apparatus comprising: a detector for detecting a predetermined cell included in a biological sample; a sample preparation section for preparing a measurement sample from the biological sample and a predetermined reagent; and a controller configured to generate, based on a detection result by the detector, concentration information reflecting a concentration of the predetermined cell in the biological sample and to control, based on the concentration information, the amount of the biological sample supplied to the sample preparation section.

Sample preparation apparatus and sample preparation method, and cell analyzer and cell analysis method

The present invention is to present a cell analyzer capable of measuring cells which are approximately 20 to 100 &#x3bc;m in size with high precision via flow cytometry. The cell analyzercomprises: a flow cellin which a measurement sample including a measurement target cell flows; a light source partfor irradiating a light on the measurement sample flowing in the flow cell; an optical systemfor forming a beam spot on the measurement sample flowing in the flow cell, the beam spot having a diameter of 3&#x2dc;8 &#x3bc;m in a flow direction of the measurement sample and a diameter of 300&#x2dc;600 &#x3bc;m in a direction perpendicular to the flow direction of the measurement sample; and a light receiving partfor receiving a light from the measurement sample.

Cell analyzer and cell analyzing method

An optical information measuring apparatus includes: a light source section capable of emitting a plurality of light beams; a light guiding section for directing and supplying the plurality of light beams from the light source section to an object; an object lens arranged facing the object; a plurality of light receiving sections for respectively receiving the light beams from the object via the object lens; and a frame section for integrally mounting a plurality of optical elements including the light source section, the light guiding section, the object lens, and the light-receiving sections.

Optical information measuring apparatus

The boundary of an object is determined based on its optically captured image by: (a) converting a density data of each of a plurality of pixels forming the captured image into a binary signal; (b) converting the binary signal into a neighbor pixel state value so that only the pixels located on the boundary r in the interior of the object have a value corresponding to the binary signals of the surrounding pixels; (c) normalizing the neighbor pixel state value using an absolute chain direction value of a previous chain direction; (d) obtaining a relative chain direction value for a pixel located on the boundary of the object in the image relative to the direction from which the chain has proceeded, with reference to the neighbor pixel state value of the pixel; (e) calculating an absolute chain direction value of a next chain direction on the basis of the relative chain direction value; and (f) repeating the steps (c) to (e) for each pixel located on the boundary to trace the boundary of the object for determining the boundary.

Method and apparatus for determining the boundary of an object

A multiple light source unit includes a plurality of light sources for emitting light beams. There is a condensing lens and the light beams are parallel to an optical axis of the condensing lens. Included is a mirror for directing the light beams from the plurality of light sources to the condensing lens. A light guiding element for receiving the condensed light beams through a light receiving section and for emitting the light beams through a light emitting section is also provided. The light beams from the plurality of light sources are incident, through respective positions on the condensing lens, into the light receiving section of the light guiding element.

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Himeji, Japan

Masaki Ishisaka