Canon U.s.a., Inc.

The General Hospital Corporation

Masaki Hosoda

Haruo Nakaji

Milen Stefanov Shishkov

Zhuo Wang

Seemantini K Nadkarni

Shishkov Milen

There is provided a new apparatus, system, and method of use for laser speckle imaging that allows for omni-directional viewing. The omni-directional viewing can include a reflector and switches configured for switching the illumination on the luminal tissue such that the light reflected from the luminal tissue at any given time is reflected from one or more substantially non-overlapping sections of a luminal tissue. This apparatus may be particularly useful for tissue analysis such as analysis of vulnerable plaque.

Omni-directional viewing apparatus

The present disclosure relates in general to Diffuse Correlation Spectroscopy system for obtaining an autocorrelation function, and more particular, to a correlator and method for controlling a sampling time period and data length used for calculating an autocorrelation function. The correlator may include, a sampling gate circuit which is open during a variable time period and provides a data sample, a correlation circuit which calculates a correlation function from the data sample provided from the sampling gate circuit, and a parameter determining circuit which determines a sampling time period to be used by the sampling gate circuit based on the correlation function.

Correlator with a variable sampling time scheme

One or more spectrally encoded endoscopy (SEE) devices, systems, methods and storage mediums for characterizing, examining and/or diagnosing, and/or measuring viscosity of, a sample or object using speckle detection are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments. Preferably, the SEE devices, systems methods and storage mediums include or involve speckle intensity autocorrelation function(s). One or more embodiments involve a serial time-encoded 2D imaging system with speckle detection to reconstruct images, store reconstructed images of the sample or object, and/or measure viscosity of the sample or object.

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Cambridge, MA, United States of America

Masaki Hosoda