Panasonic Corporation

Panasonic Healthcare Holdings Co., Ltd.

Phc Holdings Corporation

Matsushita Electric Industrial Co., Ltd.

Panasonic Healthcare Co., Ltd.

Central Glass Company, Limited

Nec Tokin Corporation

Masaki Fujiwara

Shoji Miyazaki

Shin Ikeda

Eriko Yamanishi

Yoshinobu Tokuno

Yoshinori Amano

Hiroyuki Tokunaga

Teppei Shinno

Tomohiro Yamamoto

Takahiro Nakaminami

Toshihiro Akiyama

Kenichi Hamanaka

Keisuke Matsumura

Junko Nakayama

Masataka Nadaoka

Koji Miyoshi

Motonori Uchiyama

Takeshi Nishida

Toshiki Matsumoto

Yoshifumi Takahara

Takaaki Fujii

Yohei Hashimoto

Setsuko Yano

Fuminori Kutsuna

Toshihiko Nishiyama

Gaku Harada

Noriyoshi Terashima

Shinya Akiba

Shinako Okada

Tetsuya Takashima

Takaaki Yoshimura

Kiyohiro Horikawa

Masahiro Kitagawa

Shusei Aibara

Toshihiko Oono

Katsumi Iwao

The present invention provides a method for accurately measuring a blood component despite uneven distribution of blood introduced into a capillary. The measurement method according to the present invention is characterized in that a plurality of electrode systems for measuring the hematocrit are provided in a capillary of a biosensor to measure the hematocrit at different positions in the capillary. By measuring the hematocrit at the plurality of positions in the capillary as described above, the hematocrit can be measured mom accurately despite uneven distribution of blood introduced into the capillary.

Method for measuring amount of blood component in blood

The present invention provides a method for accurately measuring a blood component despite uneven distribution of blood introduced into a capillary. The measurement method according to the present invention is characterized in that a plurality of electrode systems for measuring the hematocrit are provided in a capillary of a biosensor to measure the hematocrit at different positions in the capillary. By measuring the hematocrit at the plurality of positions in the capillary as described above, the hematocrit can be measured more accurately despite uneven distribution of blood introduced into the capillary.

It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair, which composes a biosensor, to obtain a first response value, a second voltage is applied to an electrode pair, which composes the biosensor, to obtain a second response value, and a current that is generated when a third voltage is applied to an electrode pair, which composes the biosensor, is detected to obtain a third response value. A liquid sample measurement deviceuses the first response value, the second response value, and the third response value to obtain the concentration of glucose and the amount of blood cells of blood as well as the value equivalent to the temperature of the biosensor

Liquid sample measurement device, liquid sample measurement method, and biosensor

Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (), a counter electrode (), and a blood sample holding part () having branch parts (). A first reagent () consisting essentially of an oxidant in a redox substance is disposed in contact with the surface of a counter electrode which faces the branch part (), and a second reagent () consisting essentially of a reductant is disposed in contact with the surface of a working electrode that faces the branch part ().

Method for measuring hematocrit value of blood sample, method for measuring concentration of analyte in blood sample, sensor chip and sensor unit

The concentration measurement method includes: introducing a predetermined amount of the biological sample into the capillary; measuring a temperature of the biological sample by applying a first voltage to the electrode unit when the temperature of the biological sample is measured, the first voltage allowing the temperature measurement to be less affected by increase and reduction in an amount of the analyte contained in the biological sample; measuring the concentration of the analyte contained in the biological sample by applying a second voltage to the electrode unit; measuring an environmental temperature in a surrounding of the biological sample; and correcting the concentration of the measured analyte based on the measured temperature of the biological sample and the measured environmental temperature.

Method for measuring temperature of biological sample, measuring device, and biosensor system

Provided is a blood component measuring device or the like that can further suppress the measurement error of a blood component. The device detects an oxidation-reduction current generated by oxidation-reduction when a first voltage is applied to a first electrode pairof a biosensor, and converts the oxidation-reduction current (glucose response value) into a glucose conversion value. The device detects a current generated when a second voltage is applied to a second electrode pairof the biosensor, and converts the detected current (blood cell amount response value) into a blood cell amount conversion value. The glucose response value is measured more than once and the blood cell amount response value is also measured more than once within a predetermined period after the introduction of the blood into the biosensor. A CPUcorrects the glucose conversion value measured within the predetermined period based on at least a part of a plurality of glucose conversion values and a plurality of blood cell amount conversion values obtained from the results of measurement.

Blood component measuring device, method for measuring blood component, and bio-sensor

The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor systemincludes a measuring instrumenthaving an operation part, and a sensor chipthat is insertable into and removable from the measuring instrumentand into which a blood sample is introduced. The sensor chipincludes a measurement part(a measurement part A) that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the blood sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part(a measurement part B) that acquires, from the blood sample, Data b for temperature correction of Data a. The operation parthas a function of determining the concentration of the analyte in the blood sample, with the concentration having been corrected according to the temperature of the blood sample based on Data a and Data b.

Biosensor system, sensor chip, and method of measuring analyte concentration in blood sample

Provided are a blood component measurement device and the like capable of further suppressing the errors in measuring blood components. A first current value that is generated by oxidation-reduction when a first voltage is applied to a first electrode paircomposing a biosensoris measured, a second current value that is generated when a second voltage is applied to a second electrode paircomposing the biosensoris measured, and then the first current and the second current are converted to give a blood component amount. Within a predetermined period after the introduction of blood into the biosensor, the first current is measured multiple times and the second current is measured once. A CPUconverts a plurality of first current values and the second current value to obtain a plurality of blood component amounts and calculates the blood component amount for the blood introduced into the biosensorfrom said plurality of blood component amounts.

Blood component measurement device and blood component measurement method

It is intended to provide, for example, a liquid sample measurement device capable of measuring the amounts of components of a liquid with a high accuracy. A first voltage is applied to an electrode pair, which composes a biosensor, to obtain, a first response value, a second voltage is applied to an electrode pair, which composes the biosensor, to obtain a second response value, and a current that is generated when a third voltage is applied to an electrode pair, which composes the biosensor, is detected to obtain a third response value. A liquid sample measurement deviceuses the first response value, the second response value, and the third response value to obtain the concentration of glucose and the amount of blood cells of blood as well as the value equivalent to the temperature of the biosensor

There are provided a biosensor, and a measurement device in which the biosensor is used, with which accurate puncture is enabled and reliability of measurement results are improved. The biosensor comprises an element substrate, a detector, a connection terminal, a continuity path, and a cutout. The detector is provided over the element substrate, and receives a specimen and detects a specific component contained in the specimen. The connection terminal is provided over the element substrate and acquires current corresponding to the specific component. The continuity path connects the connection terminal and the detector. The cutout is formed along the outer periphery of the detector so as to surround two or more directions of the detector.

Biosensor, cartridge storing biosensor, measurement device using biosensor

Provided is a method for measuring a blood component amount that can sufficiently and properly correct the blood component amount by measuring an Hct value with high accuracy and high reliability, and a sensor and a measuring device that are used in the method. A method for measuring a blood component amount uses a biosensor to calculate a blood component amount in blood. The biosensor includes the following: a first electrode system having a first working electrode and a first counter electrode; a second electrode system having a second working electrode and a second counter electrode; and a reagent portion arranged in a form that covers at least a part of the first electrode system, but does not cover the second working electrode. The method includes the following: a first step of detecting a first current value that flows through the first electrode system and calculating an apparent blood component amount in the blood based on the first current value, during a period in which a first voltage is applied to the first electrode system and a second voltage is applied to the second electrode system while the first voltage is being applied; followed by a second step of stopping the application of the first voltage to the first electrode system, applying a third voltage to the second electrode system, and detecting a second current value; and a step of calculating a true blood component amount using the apparent blood component amount and the second current value.

Method of measuring blood component amount

Provided is a sensor chip for electrochemically measuring a concentration of an analyte in a blood sample. In one embodiment of the sensor, the sensor chip includes a substrate, and a preliminary measurement analyzer and a hematocrit value analyzer disposed on the substrate. The preliminary measurement analyzer includes a preliminary working electrode and a preliminary counter electrode. The hematocrit value analyzer includes a working electrode and a counter electrode. An oxidant of a redox substance is disposed on the preliminary measurement analyzer and the counter electrode. A reductant of a redox substance is disposed on the working electrode.

Growing community of inventors

Ehime, Japan

Masaki Fujiwara