Daiichi Sankyo Company, Limited

Masakazu Wakayama

Yoshitaka Nakamura

Masayuki Murakami

Yutaka Kitagawa

Makoto Imai

Makoto Yamaoka

Takafumi Kitawaki

Kazutoshi Ukai

Yukito Furuya

Eiji Numagami

Takumi Nakajima

Ayako Saito

Kazuhiro Umeo

Fumihiko Toriyama

An object of the present invention is to provide an optically active bicyclic &#x3b3;-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I'), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein Rand Reach represent a C1-6 alkyl group or the like; and Rrepresents a cyano group or the like, 

Preparation method for optically active bicyclic gamma-amino acid compound

A method for manufacturing a compound represented by the following formula (13): wherein Rrepresents a C-Calkyl group and Ac represents an acetyl group, comprising:reacting a compound represented by the following formula (12): wherein Rrepresents a C-Calkyl group, Ac represents an acetyl group and Boc represents a tert-butoxycarbonyl group, with water.

Method for manufacturing neuraminic acid derivatives

A method of manufacturing a compound represented by the formula RC(OR), wherein Rrepresents a C-Calkyl group and Rrepresents a C-Calkyl group by reacting a compound represented by the following formula (15): wherein Rrepresents a C-Calkyl group, Rrepresents a C-Calkyl group and X represents Cl, Br, I, HSOor NO, with a compound represented by the formula R&#x2014;OH, wherein Rrepresents a C-Calkyl group, in a solvent which forms a bilayer system.

Methods for manufacturing neuraminic acid compounds and synthetic intermediates of neuraminic acid compounds, including a method for manufacturing a compound represented by wherein Rrepresents a C-Calkyl, Rrepresents a C-Calkyl, Rand Rrepresent a hydrogen atom, a C-Calkyl or a phenyl, or Rand Rtogether form a tetramethylene, a pentamethylene or an oxo, and Ac represents an acetyl, comprising reacting a compound represented by wherein Rrepresents a C-Calkyl, Rrepresents a C-Calkyl, Rand Rrepresent a hydrogen atom, a C-Calkyl or a phenyl, or Rand Rtogether form a tetramethylene, a pentamethylene or an oxo, with trimethylsilyl azide in the presence of a Lewis acid.

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Kanagawa, Japan

Masakazu Wakayama