Daiichi Sankyo Company, Limited

Masakazu Tamura

Makoto Koizumi

Yuji Kasuya

Yoshiyuki Onishi

Takako Niwa

Daisuke Nishimiya

Mamoru Otoyo

A novel peptide which comprises an amino acid sequence represented by SEQ ID NO: 23, and specifically inhibits the protease activity of a target molecule.

Peptides inhibiting KLK1, KLK4, or KLK4 and KLK8

The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Cationic lipid

To provide a method for screening using cultured cells, intended to find a compound which increases the amount of sphingosine-1-phosphate or dihydrosphingosine-1-phosphate by SPL inhibitory activity rapidly, simply and highly sensitively. Provided are: a rapid and simple measurement method employing a scintillation proximity assay (SPA); a method with greatly improved detection sensitivity to the activity of a compound by controlling the concentration of the vitamin Bgroup in a culture medium to be used in assaying; and others.

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Tokyo, Japan

Masakazu Tamura