Daiichi Sankyo Company, Limited

Masakazu Nakadai

Takahiro Yamaguchi

Kozo Oda

Naoki Terasaka

Kazuhiko Tamaki

Daisuke Nakai

A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R: &#x2014;COR(wherein R: alkyl, optionally substituted alkoxy or optionally substituted amino); R: H, OH, alkoxy, optionally substituted amino, etc.; R: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; Rand R: H, optionally substituted alkyl, halogeno, etc.; Rand R: H, alkyl; R: &#x2014;XR[wherein R: &#x2014;COR(wherein R: OH, optionally substituted alkoxy, optionally substituted amino, etc.), &#x2014;SOR(wherein R: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X: single bond, optionally substituted alkylene, etc.]; X: &#x2014;NH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Y: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.

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Tokyo, Japan

Masakazu Nakadai