Zeria Pharmaceutical Co., Ltd.

Zeria Pharmaceuticals Co., Ltd.

Masakazu Murata

Masaaki Nagasawa

Naoyoshi Miura

Katsuo Shinozaki

Kiyoto Maeda

Hiroyasu Nishioka

Shigeru Ueki

Tomoyuki Yoneta

Nobuo Kawase

Hideki Nakamura

Nobuyuki Tanaka

Ryu Nakao

Tadashi Kurimoto

Osamu Kitagawa

Yoshihiko Itokazu

Hiroaki Taguchi

Yugo Matsunaga

Naoki Tsuzuike

Yuko Hori

An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like. The above-mentioned object can be achieved by carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof, wherein the carbazole derivatives are represented by the following general formula (I): (In the formula (I), the ring A represents phenyl group or the like; X represents &#x2014;O&#x2014; or the like; Y represents &#x2550;N&#x2014; or the like; a and b represent methylene group or the like; both V and Z represent &#x2014;O&#x2014; or the like; W represents a C-Calkylene group whose 1 or 2 hydrogen atoms may be substituted by a phenyl group or a C-Calkyl group; 1,2-phenylene group; 1,3-cyclohexyl group; or the like; Rrepresents methyl group or the like; Rrepresents methoxy group or the like; and Rrepresents carboxy group or the like.).

Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof

The invention provides a compound which exhibits satisfactory peroral absorbability and excellent antagonistic activity against NK-1 receptor or NK-2 receptor. The compound is a benzylamine derivative represented by formula (1) or a salt thereof 

Benzylamine derivative

Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same

Colonic motor dysfunction remedies comprising aminothiazole derivatives as active ingredients

1,5-benzodiazepine derivatives

1,5-Benzodiazepine derivatives represented by formula (I), salts thereof, and medicines containing the same as the active ingredient:

1,5 Benzodiazepine derivatives

Aminothiazole derivative, medicament containing the same, and

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Saitama, Japan

Masakazu Murata