Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Masakazu Hashimoto

Hidefumi Yoshinaga

Hiroyuki Nakagawa

Taro Kato

Lars O Tjernberg

Bengt Winblad

Yoshiharu Uruno

Mikio Aoki

Hidetaka Nagata

The present invention provides an agent for determining Alzheimer's disease, comprising an anti-S38AA antibody, a method of determining Alzheimer's disease in a test animal, comprising detecting an S38AA fragment in a sample collected from said animal, and a method of screening for a substance that treats or prevents Alzheimer's disease, comprising contacting a test substance with a cell permitting measurement of production of a S38AA fragment, measuring the production amount of the S38AA fragment in the cell, and comparing the production amount with that of the S38AA fragment in a control cell free of contact with the test substance, and selecting a test substance that down-regulates the production amount of the S38AA fragment as a substance capable of treating or preventing Alzheimer's disease, based on the comparison results.

Diagnostic drug and diagnostic method for Alzheimer's disease

The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine Dreceptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; Ris Calkyl group, Ccycloalkyl group, or amino group; Ris hydrogen atom, Calkyl group or the like, provided that when Ris amino group, then Ris hydrogen atom; Rand Rare independently hydrogen atom, or Calkyl group; Rand Rare independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond. 

Cyclic aminomethyl pyrimidine derivative

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Suita, Japan

Masakazu Hashimoto