Sysmex Corporation

Toa Medical Electronics Co., Ltd.

National Institute of Advanced Industrial Science and Technology

Wako Pure Chemical Industries, Inc.

Fujifilm Wako Pure Chemical Corporation

Masakazu Fukuda

Masamichi Tanaka

Masaki Ishisaka

Yousuke Tanaka

Hiroyuki Nakamoto

Hiroaki Tateno

Hiromi Onomichi

Yanyan Liu

Masaki Warashina

Ryuichiro Ebi

Koki Tajima

Jun Hirabayashi

Junya Inoue

Hironori Kobayashi

Makoto Asashima

Kazuyuki Kanai

Shota Tateyama

Kazuki Kishi

Hiroyuki Seshimo

Junyi Ding

Yuzuru Ito

Yasuko Onuma

Hidemichi Tohori

Masatsugu Ozasa

Atsushi Kuno

Toshihiro Ootani

Masayuki Katayama

Rumi Takata

Kanako Nagaoka

Mitsumasa Sakamoto

Junzo Yamamoto

Yutaka Ikeda

Nobuhiro Kitagawa

Toshikuni Suganuma

Masaaki Oka

Kazunari Hirayasu

Ryosuke Fujii

Takumi Inutsuka

Kazuhiro Kanou

Mayumi Kamo

Kurayoshi Iseki

Akito Terai

Tomoyuki Tsukahara

Teruya Matsumoto

Hiromi Onomochi

A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.

Urine analysis system, image capturing apparatus, urine analysis method

Provided is a biological sample imaging device and a biological sample imaging method that are capable of disposing a sufficient number of large-sized particles in a biological sample so as to be moderately dispersed within an imaging range. The biological sample imaging method includes: a first step of introducing a biological sample containing particles into a liquid flow channel; a second step of causing the biological sample introduced into the liquid flow channel to flow in a forward direction; a third step of causing the biological sample to flow in a reverse direction after the second step; and an imaging step of taking, in an imaging cell, images of the particles contained in the biological sample that remains in the liquid flow channel after the third step.

Biological sample imaging device and biological sample imaging method

Disclosed is a bacteria analyzing method comprising: irradiating with light a measurement sample prepared by mixing a specimen and a reagent; obtaining two types of optical information from each of at least some particles contained in the measurement sample; and generating a measurement result of the specimen with a flag representing morphological characteristics of bacteria contained in the specimen based on both of: (i) information indicative of a characteristic of a distribution pattern of particles plotted in a first region of a coordinate space including at least two axes, wherein the two types of optical information are scalable along the respective axes, and (ii) information representing a number of particles plotted in a second region being a part of the first region.

Bacteria analyzing method and specimen analyzer

The urine analyzerincludes a sample preparation unitfor mixing a urine sample with a hemolytic agent to prepare a measurement sample, a flow cellfor flowing a measurement sample, a light sourcefor irradiating light on the measurement sample flowing through the flow cell, a light receiving unitfor receiving scattered light given off from the measurement sample by irradiation of light and outputting a scattered light signal, and an analysis unitfor detecting fat particles in the measurement sample by using a parameter reflecting the intensity of the scattered light signal output by the light receiving unit, and a parameter reflecting the width of the scattered light signal.

Urine analyzer and urinalysis method

Provided are a cell imaging device and a cell imaging method that can shorten the time period of taking images of cells in a liquid sample, compared with conventional techniques. This cell imaging device introduces a urine sample containing cells into an internal space of a sample cell, moves at least one of the sample cell and an objective lens in a second direction while at least one of the sample cell and the objective lens is moved in a first direction, the second direction being different from the first direction, and takes, at a plurality of imaging positions, images of cells contained in the urine sample by means of an imaging unit.

Cell imaging device, cell imaging method, and sample cell

A cell imaging apparatus captures images of cells contained in a liquid specimen comprising: an image capture unit including an objective lens, specimen cells each including an inner space which is capable of holding a liquid specimen and which is elongated in one direction, the specimen cells arranged such that the inner spaces are aligned in a row in a longitudinal direction of the inner spaces, a drive unit that moves at least one of: a) one or more specimen cells; and b) the objective lens; and a controller that controls the drive unit to move at least one of: a) one or more specimen cells; and b) the objective lens in the longitudinal direction and controls the image capture unit to capture images of cells contained in a liquid specimen held in the inner space of each of the specimen cells at multiple image capture positions.

Cell imaging apparatus and cell imaging method

Provided is a method for detecting a stem cell based on an undifferentiated sugar chain marker having a specific sugar chain structure, wherein the stem cell is detected by detecting podocalyxin contained in a culture supernatant or a lysate of cells by a 'lectin-antibody sandwich method' using a combination of a lectin and an antibody and having high sensitivity, the method including steps of: contacting the culture supernatant or the lysate, a lectin capable of binding to a sugar chain represented by (Formula 1) or (Formula 2), and an antibody capable of binding to keratan sulfate to form a complex composed of the lectin, podocalyxin and the antibody; and detecting the complex. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule.

Method and kit for detecting stem cell

Disclosed is a sample analyzer comprising: a sample measuring section including a detecting section for detecting a component contained in a sample and a flow path for feeding the sample to the detecting section; and a control section. The control section is programmed to automatically control the sample measuring section to flow a sample blank free of particles to the detecting section and detect a component contained in the sample blank to check a background of the detection after the sample measuring section performs washing of the flow path.

Sample analyzer and method for controlling a sample analyzer

A urine analyzer capable of operating in a urine measurement mode and a body fluid measurement mode, the urine analyzer includes a specimen preparing section configured to prepare a measurement specimen and a detecting section configured to derive signals of particles in the measurement specimen supplied from the specimen preparing section. A computer and a memory including programs on a computer-readable medium that enable the computer to execute operations to control the specimen preparing section and the detecting section in the urine measurement mode and in the body fluid measurement mode.

Urine sample analyzer and sample analyzing method

A cell analysis apparatus includes an optical detection section that accommodates a flow of a measurement sample obtained from a biological sample and a pigment into a flow cell. A light source irradiates the measurement sample flowing in the flow cell and a fluorescence detector detects fluorescence from the measurement sample. A signal processing circuit acquires a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal, and a system control section distinguishes between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value of the fluorescence signal obtained by the signal processing circuit.

Cell analysis apparatus and cell analysis method

A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided. The cell analysis apparatus () includes: an optical detection section () for flowing a measurement sample obtained from a biological sample and a pigment into a flow cell (), irradiating the measurement sample flowing in the flow cell () with laser beam and detecting fluorescence from the measurement sample; a signal processing circuit () for acquiring, based on a fluorescence signal outputted from the detection section (), a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal; and a system control section () for distinguishing between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value reflecting the height of the waveform of the fluorescence signal and the value reflecting the length of the ridge line of the waveform of the fluorescence signal obtained by the signal processing circuit ().

A sample processing apparatus comprises an aspirating member which comprises a pump at one side and which is configured to aspirate a sample from the other side, a sensor which is configured to sense the presence or absence of a liquid at a predetermined position of the aspirating member, and a controller which is programmed to execute operations. The operations comprise controlling the aspirating member to aspirate a sample, obtaining a first sensing result by the sensor when the aspirating member aspirates a sample, controlling the aspirating member to aspirate air after aspirating a sample, obtaining a second sensing result by the sensor when the aspirating member aspirates air, and detecting an error in the aspirating operation, based on the first sensing result and the second sensing result.

Sample processing apparatus and an error detecting method for sample processing apparatus

An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is 'undifferentiation sugar chain marker' composed of the sugar chain structure 'Fuc&#x3b1;1-2Gal&#x3b2;1-3GlcNAc' or &#x201c;Fuc&#x3b1;1-2Gal&#x3b2;1-3GalNAc&#x201d; and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells. Also found is BC2LCN lectin or a modified product thereof capable of sensitively recognizing the &#x201c;undifferentiation sugar chain marker&#x201d; as excellent &#x201c;probe for detecting the undifferentiation sugar chain marker&#x201d; capable of determining the undifferentiation status of cells using a culture supernatant.

Undifferentiated cell detection method and complex carbohydrate detection method

A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell Cin the biological sample from passing and allows a second cell Chaving a smaller diameter than that of the first cell Cto pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid Lmainly including the first cell Cand a second liquid Lmainly including the second cell C. A measurement target cell filtered by the filter among other cells can be easily collected.

Cell processing apparatus, sample preparation apparatus, and cell analyzer

Growing community of inventors

Kobe, Japan

Masakazu Fukuda