Shimadzu Corporation

Masakazu Akechi

Masaki Kanai

Nobuhiro Hanafusa

Takahiro Nishimoto

Yoichi Fujiyama

Hirohisa Abe

Tomoaki Tsuda

Nobuya Hashizume

Takeshi Iharada

Takeaki Inoue

Akira Oishi

A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90&#xb0; or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.

Dispensing device

Micro droplets are accurately placed in a reaction well. The reaction well () is formed in one surface of a well base (). A channel base () is placed on the well base (). The channel base () has, in its surface joined to the well base (), a liquid introduction channel () and a reaction well air vent channel (). The channel base () also has a recess () formed opposite to the reaction well () and recessed upward from the upper surface of the liquid introduction channel (). When viewed from above, a shoulder part () of the recess () is placed near the connection part between the reaction well () and the liquid introduction channel () and is closer to the center of the reaction well () than a shoulder part () of the reaction well ().

Micro droplet operation device and reaction processing method using the same

A display device, a display method, and a display program used in a measurement system capable of facilitating positioning in a measurement information image by displaying an IP (imaging plate) image having measurement information for &#x3b2;+ rays contained in blood to be measured and appending a guide G based on design information of a disc housing the blood to an IP image and displaying the image. The guide G is appended to an IP image in which a guide is not originally reflected, which makes it possible to visually discern a reference position (for example, the central position of the disc) in the IP image based on design information. As a result, it is possible to facilitate positioning in the IP image based on the guide G indicating the reference position (central position of the disc).

Display device, display method, and display program used in measurement system

In order to control bubble removal or mixing in a flow channel, bubble transfer between flow channels () is controlled by disposing first flow channel () for flow of a first fluid of liquid or gas and second flow channel () for flow of a second fluid of liquid with, interposed therebetween, gas exchange unit () through which while no liquid can pass, a gas component can be transferred, and by providing a pressure difference between the flow channels () with the gas exchange unit (). By rendering the pressure of the second flow channel () higher than that of the first flow channel (), any bubble transfer from the first fluid to the second fluid is prevented, or bubbles within the second fluid are transferred into the first fluid to thereby attain deaeration.

Method for controlling pressure-difference bubble transfer

A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90&#xb0; or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.

A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part and carbon dioxide separation part and conductivity measuring part, control unit and data processing unit. In order to enhance the accuracy of conductivity measurement, the control unit is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part and carbon dioxide separation part. The data processing unit is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part.

Total organic carbon measuring instrument

[PROBLEMS] To increase the rate of gas transfer in gas exchangers. [MEANS FOR SOLVING PROBLEMS] A gas exchange chip comprises substrates (); two flow channels () formed in the substrates () and each having an inlet port and an outlet port; and multiple grooves () interlinking the flow channels (). The grooves () have the size of their sectional area predetermined and have at least a part of the internal surface thereof rendered hydrophobic so as to permit the transfer of gas component while inhibiting any liquid passage. A sample water containing carbon dioxide is caused to flow through one of the flow channels () while pure water is caused to flow through the other flow channel () to thereby transfer the carbon dioxide contained in the sample water into the pure water.

Gas exchange chip

Disclosed is a total organic carbon (TOC) measurement apparatus capable of facilitating reduction in size of the apparatus and achieving enhanced measurement accuracy. The TOC measurement apparatus includes an organics oxidation unit, a carbon-dioxide separation unit and a conductivity measurement unit, which are integrally formed by laminating a plurality of plates to define therebetween and incorporate therein an oxidizing flow passage, an aqueous-sample flow passage, a gas permeable membrane, a measurement-water flow passage and a conductivity measuring electrode. The TOC measurement apparatus is designed such that carbon oxide in an aqueous sample is transferred from the aqueous-sample flow passage to the measurement-water flow passage through the gas permeable membrane, and a conductivity of measurement water which contains the carbon oxide and flows through a flow passage facing the conductivity measuring electrode is determined and converted to a TOC content.

Apparatus for measurement of total organic carbon content

An apparatus which comprises: an organic-substance oxidation part in which organic substances contained in a sample water supplied are oxidized into carbon dioxide; a carbon dioxide separation part in which the carbon dioxide contained in the sample water is caused to permeate and come into a measurement water; and a conductivity measurement part in which the conductivity of the measurement water is measured. The carbon dioxide separation part comprises: a sample water channel in which sample water flows; an intermediate water part in which intermediate water having a higher pH value in a neutral region than the sample water is present; and a measurement water channel through which the measurement water comprising deionized water flows. The sample water channel is in contact with the intermediate water part through a gas-permeable membrane, and the intermediate water part is in contact with the measurement water channel through a gas-permeable membrane.

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Kyoto, Japan

Masakazu Akechi