Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Mitsubishi Kasei Corporation

Meiji Seika Kabushiki Kaisha

Meiji Saika Kaisha, Ltd.

Meuji Seika Kaisha Ltd.

Masaji Sezaki

Shinichi Kondo

Takashi Shomura

Haruo Yamamoto

Masao Koyama

Shuichi Gomi

Shinji Miyadoh

Tomio Takeuchi

Takashi Tsuruoka

Masa Hamada

Yoshikazu Sato

Tadashi Nakazawa

Takeshi Hara

Shigeharu Inouye

Katsuyoshi Iwamatsu

Kiyoaki Katano

Toru Sasaki

Hiroko Ogino

Michiaki Iwata

Kazunori Ohba

Noriko Takahashi

Haruyuki Ohkishi

Hiroomi Watabe

Takashi Mikawa

Takashi Yoshida

Masaru Shimura

Seiji Shibahara

Taro Niida

Nobuto Minowa

Mitsugu Hachisu

Takashi Yaguchi

Shigeharu Inoue

Tomizo Niwa

Satoru Nakabayashi

Michio Kojima

Norio Ezaki

Fumio Kai

Tomoya Machinami

Yasuharu Sekizawa

Uichi Shibata

Takemi Koeda

Harumi Fukuyasu

Yasumitsu Kondo

Tsutomu Tsuruoka

Masayuki Takagi

Shigeharu Inoye

Tatsuo Ito

Hiromi Watanabe

Mieko Nagasawa

Tadaaki Okada

Takao Shimizu

Naotoshi Akai

Junko Yoshida

Kazuko Mizutani

Kunihiko Kurihara

Masashi Niida

Shiro Sakakibara

Kei-ichi Imamura

Masashi Miyamoto

Keizo Shimomura

Kazuo Okano

Tatsuo Itoh

Ryoichi Okamoto

Shigetaka Ishii

Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.

Process for the simultaneous production of benanomicins A and B

This disclosure describes a novel antibiotic designated Vermisporin produced in a microbiological fermentation using, for example, a new strain of Ophiobolus Vermisporus L-8. This novel antibiotic is an active antibacterial, especially anti-anaerobic bacterial agent.

Strain Ophiobolus vermisporus FERM BP-1636

A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.

Xanthocillin X monomethyl ether derivative and antitumor agent

2,3-disubstituted-4-hydroxyquinoline derivatives of the general formula (I): ##STR1## [wherein R.sup.1 represents a hydrogen atom or R.sup.3 CO-- (wherein R.sup.3 is a lower alkyl group); R.sup.2 represents a hydrogen atom, --CH.sub.3 or --C.sub.2 H.sub.5 ; A represents ##STR2## and W represents a hydrogen atom, or 1- 4 halogen atoms or alkyl groups which are substituted at the nucleus and may be the same or different] have a strong antagonistic action on leukotriene D.sub.4.

2,3-disubstituted-4-hydroxyquinoline derivatives

A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.

PF 1022 substance, method of treating helminthic parasitic infection and

Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.

Antibiotics, dexylosylbenanomicin B

Benanomicins A and antibiotic compositions

Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.

Sulfonyl derivatives of an antibiotic substance isolated from

Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

Cephalosporin compounds and antibacterial agents

A novel compound having an intense insecticidal activity and a process for producing the same which comprises culturing a strain belonging to the genus Humicola and isolating the compound from the culture.

Compound having insecticidal activity and insecticide composition

Certain anti-tumor duocarmycin antibiotics from streptomyces

An antibiotic substance represented by formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, which is produced by cultivating a microorganism belonging to the genus Streptomyces and isolating the substance from the cultured cells.

Novel antitumor antibiotic substance and a method for production thereof

Novel antibiotic vermisporin, process for the production thereof and

Fluorophthalimide compounds represented by the following general formula (I): ##STR1## wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.

Fluorophthalimides and agricultural and horticultural fungicides

Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):

Cephalosporin derivatives and bactericides containing the same

Growing community of inventors

Tokyo, Japan

Masaji Sezaki