Eisai Company, Limited

Arigen Pharmaceuticals, Inc.

Nagoya Institute of Technology

Gunma University

Institute of Mitochondria Science, Inc.

Nai Inc.

Link Geonomics, Inc.

Masaichi Yamamoto

Isao Yamatsu

Takeshi Suzuki

Akiharu Kajiwara

Seiichi Araki

Yoshikazu Suzuki

Haruyoshi Arai

Hiroshi Yamamoto

Kiyoshi Kita

Hiroyuki Saimoto

Haruhiko Machida

Yoshiaki Nakamura

Tadahiro Ibuki

Yoshisada Yabu

Masaharu Ito

Takeshi Toru

Shoetsu Fukuhara

Norio Shibata

Yoshihiro Shigemasa

Tadaaki Tanaka

Tomoyoshi Hosokawa

Ken Daniel Inaoka

Tomoyoshi Nozaki

The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein

Dihydroorotic and acid dehydrogenase inhibitor

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; Rrepresents a hydrogen atom; Rrepresents a hydrogen atom or a Calkyl group; Rrepresents &#x2014;CHO, &#x2014;C(&#x2550;O)R, &#x2014;COOR(wherein Rrepresents a Calkyl group), &#x2014;CHOH or &#x2014;COOH; and Rrepresents a Calkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a Calkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a Calkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

Dihydroxybenzene derivatives and antiprotozoal agent comprising same as active ingredient

Disclosed are: a compound which is stable in an acid, has an antibacterial effect against a bacterium, can exert a satisfactory level of an antibacterial effect when used singly, does not affect an enteric bacterium, has an antibacterial effect against a bacterium resistant to an antibacterial agent, and has an inhibitory effect on gastric acid secretion; and a pharmaceutical composition comprising the compound. Specifically disclosed are: a compound represented by the general formula (I) or a salt thereof; and a pharmaceutical composition comprising the compound or the salt thereof: wherein R represents a linear alkyl group having 4 to 8 carbon atoms, preferably 5 to 7 carbon atoms.

Helicobacter pylori eradicating agent having inhibitory activity on gastric acid secretion

A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the same as an active ingredient have excellent antiviral properties and are useful as antiviral therapeutic agents: [wherein R represents a nitrogen-containing heterocyclic ring which may have any one of a C-Calkyl group or a C-Calkoxy group as a substituent, or a C-Calkyl group which has one primary amino group as a substituent].

Pyrimidine nucleoside derivatives and salts thereof

A compound represented by the formula (I) is used as an active ingredient in a medicament for treatment or prevention of infectious diseases caused by protozoa or bacterium.   

Trihalomethionine derivative and pharmaceutical product containing the same

Phenol derivatives and antitrypanosoma preventive/therapeutic agent comprising the same as active ingredient

A method for the treatment and prevention of herpes zoster using 5-[(E)-2-halogenovinyl] arabinofuranosyl uracil of the following general formula (1): 

Method for treatment and prevention of herpes zoster by topical application

A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula:

&bgr;,&ggr;-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

Beta, gamma-dihydropolyprenyl alcohol derivatives and pharmaceutical

Various .beta.,.gamma.-dihydropolyprenyl alcohol derivatives having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group are effective at pritigating stress in animals.

.beta., .gamma.-dihydropolyprenyl alcohol derivatives effective at

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and usrful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

.beta.,.gamma.-dihydropolyprenyl alcohol derivatives and pharmaceutical

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a phylactic agent against human and animal infectious diseases. Other disclosed polyprenyl compounds are also useful as such agents.

A milking apparatus comprises sets of electrodes for detecting milk flows sucked by individual teat cups capped on individual teats, tubes connected to pressure chambers of the respective teat cups, change-over valves operative to supply atmospheric pressure and vacuum periodically and alternately to the tubes, counters for counting times for non-detection of the milk flows by the sets of electrodes, and controller for actuating the change-over valves to supply only atmospheric pressure to the tubes when the counted times of the counters exceed a predetermined time.

Milking apparatus

A milk-claw includes a collecting chamber for milk is formed within a drum housing and connected to inlets and an outlet for milk respectively; inspection chambers for milk which have been defined adjacent to said collecting chamber for milk by means of a partition wall and in which part of the milk flowing in the collecting chamber for milk through said inlets flows; and electrodes for measuring the electric conductivity of the milk flowed in said inspection chambers for milk; wherein a through hole is perforated in said partition wall interposed between said collecting chamber for milk and inspection chambers so that the milk flowed in said inspection chambers for milk may flow back in the collecting chamber.

Growing community of inventors

Tokyo, Japan

Masaichi Yamamoto