Kowa Company Limited

Masahito Nakayama

Toshihito Mori

Toshimi Mizoguchi

Akio Iwasaki

Takeo Deushi

Hisakatsu Ito

Kazuhiro Kamiya

Masami Shiratsuchi

Isamu Watanabe

Shigeru Kimura

Sohei Tanabe

Hisakatsu Itoh

Takeshi Oda

Akira Murakami

Takafumi Kunieda

Masao Okuchi

Hiroyuki Ishiwata

Yoshio Takahashi

Yukihiro Okuno

A compound expressed by the formula: ##STR1## in which R.sub.11, R.sub.21 and R.sub.31 are identical with or different from each other and each denotes a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a haloalkyl group, an alkoxy group, an alkylthio group, an aryl or an aralkyl group which aromatic ring is optionally substituted appropriately by one to three substituents or a heterocyclic group optionally substituted appropriately by one to three substituents, or R.sub.11 and R.sub.21 may together form an alkylene group, Y denotes O or NOH, with a proviso that where R.sub.21 (or R.sub.11) and R.sub.31 denote a hydrogen atom at the same time, R.sub.11 (or R.sub.21) cannot represent an n-butyl group. This compound is useful as an antifungal agent.

Azoxy compounds

Novel azoxy compounds having antifungal activity and being useful for the treatment of mycoses, represented by the following formula ##STR1## are prepared by culturing a microorganism of Streptomyces sp. (KC-7367, FERM BP-1277) and separating the compounds from the culture broth.

Novel azoxy compounds and process for production thereof

A novel antibiotic designated as KA-6643 and having the formula, ##STR1## wherein R is hydrogen or --SO.sub.3 H.

.beta.-Lactam antibiotics

A-KA-6643-series antibiotic comprising at least one substance represented by any of the following formulae, or a salt or ester thereof: ##STR1## is effectively useful as an antibacterial and .beta.-lactamase inhibiting agent.

KA-6643-Series antibiotics, process for producing same and medical

An antibiotic KA-6643-A or a salt thereof having the formula: ##STR1## is produced by a process comprising the step of hydrolyzing an antibiotic KA-6643-B of the formula: ##STR2##

Process for producing an antibiotic

An antibiotic substance KA-7038 selected from the group consisting of the compounds having formulae I to VII described in claim 1, mixtures thereof and acid addition salts thereof; an antibiotic composition composed of (i) antibiotically effective amount of aforesaid antibiotic substance KA-7038, and (ii) a pharmaceutically acceptable diluent or carrier. The antibiotic substance KA-7038 can be produced by cultivating an antibiotic substance KA-7038-producing strain belonging to genus Streptomyces, for example Streptomyces sp. KC-7038, and isolating the antibiotic substance KA-7038 from the culture broth.

Process for preparation of antibiotics and biologically pure culture for

Novel antibiotics of the following structure ##STR1## wherein R represents a moiety selected from the group consisting of hydrogen, --COCH.sub.2 NH.sub.2, --COCH.sub.2 NHCONH.sub.2 and --COCH.sub.2 NHCHO; process for preparation thereof; and biologically pure culture for use therein.

Novel antibiotics, process for preparation thereof and biologically pure

Antibiotic KA-7038 and compositions containing same

Antibiotics of the KA-6606 series and pharmaceutical compositions thereof

Growing community of inventors

Higashimurayama, Japan

Masahito Nakayama