Nippon Shinyaku Company, Ltd.

Toray Industries, Inc.

Masahiro Yagi

Hiroshi Enomoto

Yoshiaki Yoshikuni

Yoshiaki Aoyagi

Shingo Matsumura

Ichiro Shirahase

Yoji Ezure

Kohei Kura

Hiromu Murai

Tatsuhiko Kono

Katsuya Ohata

Masaaki Ono

Nobutoshi Ojima

Kazuyoshi Fukata

A polyester film for recording medium, having one major surface thereof provided with a coating layer containing fine particles of 5 to 60 nm diameter and an organic compound, wherein the number of fine surface projections existing on the surface of the coating layer is in the range of 3 million to 100 million/mm, and the number of surface defects of 120 nm or greater height attributed to foreign matter contained in the film is 30/100 cmor less, and wherein the polyester contains a titanium compound substantially not having any particle diameter. Thus, there are provided a magnetic recording tape for digital data recording that can reduce dropouts and excels in durability, and further provided a polyester film that is suitable as a base film thereof.

Polyester film for recording medium and magnetic recording tape

N-aralkylmoranoline and N-aralkenylmoranoline, and their pharmaceutical acceptable non-toxic acid addition salts thereof, pharmaceutical compositions containing the same and methods of inhibiting the increase in blood sugar level by administration of the same.

Antihyperglycemic moranoline derivatives

Moranoline, or 2-hydroxymethyl-3,4,5-trihydroxy piperidine, is prepared by directly reducing an actinomycetes culture solution containing nojirimycin, followed by isolation, as for example, through the utilization of an ion exchange resin. The corresponding N-methyl derivative can be obtained through the addition of formaldehyde to the culture solution prior to the reduction.

Method for the production of 2-hydroxymethyl-3,4,5-trihydroxy piperidine

Moranolines are produced which are useful for controlling blood sugar levels.

Moranoline derivatives and process for preparation thereof

Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl ]phenoxy}propane.

Bis-piperidine compounds

2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.

Quaternary ammonium substituted N-cinnamylpiperidines

2-Hydroxymethyl-3,4,5-trihydroxy piperidine, or moranoline, is prepared by culturing a moranoline-producing strain of microorganism of the genus Streptomyces in an appropriate culture medium and thereafter isolating moranoline from the culture medium.

Process for the preparation of 2-hydroxymethyl-3,4,5-trihydroxy

2-Hydroxymethyl-3,4,5-trihydroxy-N-alkylpiperidines and their acid addition salts are antihyperglycemic agents. A typical example is 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine.

Antihyperglycemic N-alkyl-3,4,5-trihydroxy-2-piperidine methanol

2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.

Process for the isolation of 2-hydroxymethyl-3,4,5-trihydroxypiperidine

2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.

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Kusatsu, Japan

Masahiro Yagi