Nikkiso Company Limited

Masahiro Toyoda

Kunihiko Akita

Tomoya Murakami

Shinya Hasegawa

Hitoshi Goto

Akira Sugioka

Yoshihiro Mori

Satoru Kawarabayashi

Satoshi Takeuchi

Yasunobu Hagiwara

Naoyuki Aota

Tomohiro Furuhashi

Shigeaki Funamura

Fumitoshi Henmi

Akari Agata

Yasushi Takakuwa

Masatoshi Tarumi

Hikaru Ito

Takayuki Suzuki

A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps quickly and accurately grasp whether the current transition of a particular parameter is normal when compared with a transition of the particular parameter that is estimated from the histories. The blood purification system includes an extracting device capable of searching histories accumulated in a storage device and extracting, as an approximate history, a history including the particular parameter approximate to the particular parameter observed at the current time in the current session of blood purification treatment; an estimating device that estimates a transition of the particular parameter to be observed after the current time in the current session of blood purification treatment from the approximate history extracted by the extracting device; and a display control device capable of displaying the transition of the particular parameter estimated by the estimating device and the transition of the particular parameter observed in the current session of blood purification treatment simultaneously on a display.

Blood purification system

A blood purification apparatus includes a blood circuit that allows a patient's blood to extracorporeally circulate; a blood purifier between the arterial blood circuit and the venous blood circuit having a blood flow route through which the blood extracorporeally flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood purification membrane; an ultrafiltration unit that filters out water from the blood in the blood flow route through the blood purification membrane and drains the water through the dialysate flow route; and a substitution-fluid supply unit that supplies substitution fluid. The blood purification apparatus includes a plasma-flow-rate-acquiring unit that acquires a plasma flow rate or a correlation value of plasma flow rate with reference to a blood concentration detected from the patient's blood and a plasma total protein detected from the blood.

Blood purification apparatus and method of acquiring plasma flow rate on blood purification apparatus

A blood purification apparatus that accurately calculates the colloid osmotic pressure of a patient's blood. A dialyzer included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers. An ultrafiltration pump draws out water from the blood in the blood flow routes through the hollow fibers into the dialysate flow routes. Four detecting units measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. The pressures at the four positions, the transmembrane pressure difference can be calculated. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured. Referencing TMPa and TMPb, the colloid osmotic pressure of the patient's blood can be calculated. Referencing colloid osmotic pressure, the plasma total protein can be calculated. Referencing plasma total protein, the patient's state of nutrition can be estimated.

Blood purification apparatus and method of estimating patient's state of nutrition on blood purification apparatus

A connection structure includes a chamber comprising a hollow housing, a diaphragm dividing the inside of the housing into a first space and a second space, and an output port outputting a gas in the second space with deformation of the diaphragm caused by pressure of a fluid flowing into the first space; a connection part comprising a coupling connected to the output port and being attached to a pressure detection device comprising a pressure sensor for detecting pressure of the gas output from the coupling; and a seal member being sandwiched between a side surface of the output port and a side surface of the coupling and moving while changing a sealing position when connecting or extracting the chamber to/from the connection part.

Connection structure and blood purifying device

A blood purification apparatus that includes a blood circuit including an arterial blood circuit provided with an arterial puncture needle and a venous blood circuit provided with a venous puncture needle with which an access vessel is puncturable, the blood circuit allowing blood of the patient to extracorporeally circulate; a blood purifier connected to the arterial blood circuit and to the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit; a recirculating-blood-detecting unit capable of detecting recirculating blood when the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump, the recirculating blood being blood once returned to the patient from the venous blood circuit and reintroduced into the arterial blood circuit; and a recirculation-rate-calculating unit capable of calculating recirculation rate, the recirculation rate being a proportion of the recirculating blood in the blood flowing in the arterial blood circuit. The blood purification apparatus includes a control unit capable of executing a treatment mode in which blood purification treatment is performed with the blood purifier while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of normal connection where an upstream part of the access vessel is punctured with the puncture needle at a distal end of the arterial blood circuit and a downstream part of the access vessel is punctured with the puncture needle at a distal end of the venous blood circuit; and a measurement mode in which the detection of recirculating blood by the recirculating-blood-detecting unit and the calculation of recirculation rate by the recirculation-rate-calculating unit are performed while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of reverse connection where the downstream part of the access vessel is punctured with the puncture needle at the distal end of the arterial blood circuit and the upstream part of the access vessel is punctured with the puncture needle at the distal end of the venous blood circuit, the calculated recirculation rate being used in calculating blood flow rate in the access vessel that is calculable in the measurement mode.

Blood purification apparatus

A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to any event that occurs unsteadily or any transition of a parameter. The blood purification system includes an extracting unit that searches histories accumulated in a storage unit and extracts, as reference histories, a plurality of histories each including any of events having occurred during the current session of blood purification treatment or a plurality of histories each including a parameter approximate to that observed during the current session of blood purification treatment; a list-creating unit that creates a list of the plurality of reference histories extracted by the extracting unit; and a display control unit that controls the list created by the list-creating unit to be displayed on a display unit.

A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to a particular incident that occurs unsteadily. In a blood purification system, a history stored in a storage device includes particular incidents having occurred unsteadily in blood purification treatment. The blood purification system includes an extracting device capable of searching the histories accumulated in the storage device and extracting a desired one of the particular incidents, a calculating device capable of calculating a time when the particular incident extracted by the extracting device occurs a predetermined or more number of times as a frequent-occurrence time slot, and a display control device capable of displaying the frequent-occurrence time slot calculated by the calculating device on a display during a current session of blood purification treatment.

A blood-purification-treatment support system is capable of making an accurate judgement of whether or not any treatment conditions for blood purification treatment should be changed. The blood-purification-treatment support system is capable of supporting blood purification treatment. The system includes a storage device that stores patient-specific patient data that are acquired on a plurality of days including at least no-treatment days on which blood purification treatment is not conducted, an estimating device that compares the patient data for the plurality of days stored in the storage device with one another and estimates a pre-treatment patient state regarding blood purification treatment, and a judging device that judges from the pre-treatment patient state estimated by the estimating device whether or not any treatment conditions for blood purification treatment should be changed.

Blood-purification-treatment support system

A blood purification apparatus is provided that is capable of detecting an abnormal state of puncture into a blood vessel with an arterial puncture needle or a venous puncture needle. The blood purification apparatus includes an oscillating device capable of supplying an alternating current at a predetermined frequency and changing the frequency of the alternating current among a plurality of frequencies, a measuring device capable of measuring an impedance for each of the frequencies, a calculating device capable of acquiring an impedance frequency characteristic, a storage device capable of storing an impedance frequency characteristic acquired in a case of normal puncture into the patient's blood vessel with an arterial puncture needle and a venous puncture needle, and an identifying device capable of identifying whether the puncture into the blood vessel with the arterial puncture needle a or the venous puncture needle b is normal in accordance with the change observed between the impedance frequency characteristic acquired by the calculating device and the impedance frequency characteristic stored in the storage device.

A blood purification apparatus that detects dislodgement of a puncture needle is provided. The apparatus includes an arterial electrode, a venous electrode, a power source capable of causing a current to flow through an arterial puncture needle and a venous puncture needle that are stuck in a patient, a body-surface electrode closely attached to a body surface of the patient, a detection device capable of acquiring a heart rate of the patient in accordance with an electrical signal detected by the body-surface electrode, a monitoring device capable of monitoring in real time the current flowing through the arterial electrode or the venous electrode and a change in an impedance in a body of the patient that is detected by the detection device, and an identifying device capable of identifying a dislodged state where the arterial puncture needle or the venous puncture needle is dislodged from the patient, in accordance with the change in the impedance that is an object of monitoring by the monitoring device.

A blood purification apparatus with a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate flowing through the dialysate drain line. The blood purification apparatus includes a control unit that establishes a state of equilibrium where the concentration of the predetermined substance in the waste dialysate flowing through the dialysate drain line and a concentration of the predetermined substance in the blood flowing through the blood circuit are equal or approximate to each other; a storage unit that stores a value detected by the concentration-detecting unit in the state of equilibrium as an equilibrium value; and a clear-space-calculating unit that calculates clear space in accordance with the value detected by the concentration-detecting unit and the equilibrium value stored in the storage unit, the clear space being an index representing a volume of purification of a patient achieved by blood purification treatment.

A blood purification apparatus to which a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate resulting from the blood purification by the blood purifier and flowing through the dialysate drain line. The blood purification apparatus includes a control unit that establishes a state of equilibrium where the concentration of the predetermined substance in the waste dialysate flowing through the dialysate drain line and a concentration of the predetermined substance in the blood flowing through the blood circuit are equal or approximate to each other; a storage unit storing a value detected by the concentration-detecting unit in the state of equilibrium as an equilibrium value; and a clearance-calculating unit that calculates clearance in accordance with the value detected by the concentration-detecting unit and the equilibrium value stored in the storage unit, the clearance being a figure of merit representing a degree of solute removal by the blood purifier.

Provided is a blood purification apparatus which can continue to accurately monitor a blood purification treatment state even if treatment conditions are changed during blood purification treatment. The blood purification apparatus can perform real-time monitoring on the blood purification treatment state, based on a concentration change in a discharge solution which is obtained by an arithmetic device. The blood purification apparatus includes a treatment condition change device that sets or changes treatment conditions as requested, and that causes a discharge solution concentration sensor to previously detect concentration of the discharge solution under the respective treatment conditions, and a storage device that stores the concentration of the discharge solution under the respective treatment conditions which is detected by the discharge solution concentration sensor in the treatment condition change device, as a first predetermined value corresponding to the respective treatment conditions. When the treatment conditions are changed during blood purification treatment, the arithmetic device obtains the concentration change in the discharge solution, based on the first predetermined value corresponding to the changed treatment conditions among the first predetermined values stored in the storage device.

A blood purification apparatus with an arterial puncture needle or a venous puncture needle is stuck in the patient can be easily notified at the activation of a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer capable of purifying the blood, a blood pump provided to an arterial blood circuit for delivering a liquid, and a control device that executes a connected step in which the blood pump is activated when an arterial puncture needle (a) and a venous puncture needle (b) are in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient. The control device establishes, in the unconnected step, a restricted state where the behavior of the blood pump at the activation of the blood pump is restricted.

A blood purification apparatus where neither an arterial puncture needle nor a venous puncture needle is stuck in the patient can be checked automatically when it is attempted to activate a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer for purifying the blood, a blood pump provided to an arterial blood circuit for delivering liquid when activated, and a control device that executes a connected step when blood pump is activated with an arterial puncture needle (a) and a venous puncture needle (b) being stuck in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient.

Growing community of inventors

Shizuoka, Japan

Masahiro Toyoda