Sumitomo Chemical Company, Limited

Kaken Pharmaceutical Company, Ltd.

Masahiro Takeda

Kazuo Murakami

Yohei Tanaka

Takashi Miki

Hirofumi Kato

Hiroshi Kadono

Tetsuro Yamazaki

The invention relates to a method of producing compound (I) by (A) reacting compound (II) formaldehyde and hydrogen in the presence of a metal catalyst, in a solvent, wherein the amount of the formaldehyde to be used is exceeding 1 mol and not exceeding 5 mol per 1 mol of compound (II), to obtain a mixture containing the formaldehyde and compound (I), and (B) mixing the obtained mixture containing the formaldehyde and compound (I) with hydrogen and a secondary amine selected from the group consisting of diethylamine, dipropylamine, diisopropylamine, butylethylamine, pyrrolidine, piperidine and morpholine, in the presence of a metal catalyst, in a solvent, and then removing the metal catalyst, followed by obtaining the compound (I) by distillation.

Method for producing 1-methylpyrrolidin-3-ol

A method of producing a purified optically active 4-amino-3-(substituted phenyl)butanoic acid compound which is characterized by comprising a step of making a crude optically active 4-amino-3-(substituted phenyl)butanoic acid compound contact an organic acid in the presence of water.

Method of producing purified optically acitve 4-amino-3-(substituted phenyl)butanoic acid compound

Provided is a new crystal A of optically active 4-amino-3-(4-chlorophenyl)butanoic acid which is far better in stability, and a process for producing the crystal and a process for producing the crystal A comprising a step of heating the following crystal B in water having a pH of 3 to 9:

Optically active 4-amino-3-(4-chlorophenyl)butanoic acid

A method for producing a &#x3b2;-nitrostyrene compound is provided in which a benzaldehyde derivative represented by the following formula (I): and nitromethane are condensed in an acetic acid solvent in the presence of a primary amine. This method allows production of a &#x3b2;-nitrostyrene compound at a high yield in the industrially-safe reaction temperature range.

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Nishinomiya, Japan

Masahiro Takeda