Toyama Chemical Co., Ltd.

Masahiro Takahata

Hiroshi Sakai

Isamu Saikawa

Takashi Yasuda

Masaru Tai

Susumu Mitsuhashi

Yutaka Takashita

Michiko Mae

Hisatsugu Tsuda

Shohachi Murakami

Toyoo Maeda

Akira Yotsuji

Hidetada Mikami

Toshinori Ohashi

Hirokazu Narita

Yasuo Watanabe

Yozo Todo

Kazuya Hayashi

Quinolonecarboxylic acid derivatives or salts thereof

A composition comprising a component obtained by deproteinizing an extract from the poison pouch contents of bee has an immunostimulating activity, a carcinostatic activity, an effect of enhancing the antibacterial activity of an antibacterial substance and an effect of enhancing the carcinostatic activity of a carcinostatic substance. This invention is directed to a carcinostatic, immunostimulating and antibacterial agent comprising said composition.

Pharmaceutical composition comprising extract from poison pouch contents

An antibacterial composition for medical use comprising a cephalosporin or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting compound having a .beta.-lactam ring. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.

Antibacterial composition for medical use

A method for treating a host mammal having a decreased immunity, comprising administering to said host mammal an immunostimulating effective amount of the deproteinized extract from the poison pouch contents of bee B-T, is disclosed.

An antibacterial composition for medical use comprising 6-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetam ido]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.

An antibacterial composition for medical use comprising 6-[-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamid o]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.

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Kosugimachi, Japan

Masahiro Takahata