Kowa Company Limited

Masahiro Nishikawa

Yukiyoshi Yamazaki

Masahiro Tamura

Yoshinori Kyotani

Toshiaki Oda

Takeshi Doi

Tatsuhiko Kodama

Shunji Takemura

Masao Ohkuchi

Ayumu Okuda

Tsutomu Toma

Kazutoyo Abe

Hidefumi Ozawa

Soichi Oda

Takaaki Araki

Hajime Yamada

Tatsuhiko Kodoma

The present invention provides a compound selectively activating PPAR&#x3b1;, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.

PPAR-activating compound

A compound represented by the following formula (1): (wherein each of Rand R, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R, R, R, and R, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a Calkyl group, a trifluoromethyl group, a Calkoxy group, a Calkylcarbonyloxy group, a di-Calkylamino group, a Calkylsulfonyloxy group, a Calkylsulfonyl group, a Calkylsulfinyl group, or a Calkylthio group, or Rand R, or Rand Rmay be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N&#x2014;R(Rrepresents a hydrogen atom, a Calkyl group, a Calkylsulfonyl group, or a Calkyloxycarbonyl group); Y represents an oxygen atom, S(O)(l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosulfonyl group; Z represents CH or N; n is a number of 1 to 6; and m is a number of 2 to 6) or a salt thereof; and therapeutic drugs containing any of such a compound or salt.

PPAR-activating compound and pharmaceutical composition comprising the compound

A cyclic diamine compound of formula (1): wherein Rand Rare individually a hydrogen atom or a methoxy group, provided Ris a methoxy group when Ris a hydrogen atom, or a hydrogen atom when Ris a methoxy group; A is an oxygen atom, a sulfur atom, CH&#x2550;CH, CH&#x2550;N or NR, in which Ris a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; B is a nitrogen atom, CH or CR, in which Ris a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; m is 1 or 2; and n is a number of 1 to 5,an acid-addition salt thereof, or a hydrate thereof. The compound has inhibitory effects on cell adhesion and is useful for treatment of allergy, asthma, rheumatism, arteriosclerosis, and inflammation.

Cyclic diamine compound with condensed-ring groups

A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR&#x3b1;.

A cyclic amine compound represented by the following general formula (1):wherein, These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.

Growing community of inventors

Higashimurayama, Japan

Masahiro Nishikawa