Otsuka Pharmaceutical Company, Limited

Dic Corporation

Masahiro Miyake

Hidenori Ogawa

Naoto Utsumi

Shigekazu Fujita

Motoshi Matsui

Yasuaki Muguruma

Yasuhiro Torisawa

Gemma Zuend

Takashi Mukai

Masashi Hayashi

Kaoru Abe

Nipun Davar

Kimiyoshi Annaka

Yuya Nakai

Ian Scott

Iwao Miura

Takahiro Okada

Aya Asahina

The invention relates to methods of synthesizing 2'-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

2'-deoxy-2′,2′-difluorotetrahydrouridines with high purity and methods of making the same

The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the step of heating hydroquinone and 4-(4-trifluoromethoxyphenoxy)piperidine. This method can produce 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof in an industrially advantageous manner.

Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof

The present invention provides an active energy ray curable aqueous resin composition prepared by reacting an acrylic resin (A), a polyisocyanate compound (B), and (meth)acrylate (C) having a hydroxyl group and dispersing the reaction product in an aqueous medium, the resin (A) being produced by copolymerizing an acrylic monomer (a1) having a polyoxyalkylene group, an acrylic monomer (a2) having a hydroxyl group, and an acrylic monomer (a3) other than the acrylic monomer (a1) and the acrylic monomer (a2) as essential raw materials. The active energy ray curable aqueous resin composition has excellent storage stability and forms a cured coating film with a good appearance and high adhesion to a substrate even after immersion in hot water, and thus can be desirably used for an active energy ray curable aqueous coating material.

Active energy ray curable aqueous resin composition, active energy ray curable aqueous coating material, and article coated with the coating material

This invention provides a process for preparing benzazepine compounds of the formula (1): wherein Xis a halogen atom, Rand Rare a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.

Process for preparing benzazepine compounds or salts thereof

This invention provides a process for preparing benzazepine compounds of the formula (1): wherein Xis a halogen atom, Rand Rare a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity. 

In the IR (Inversion Recovery) method, to observe a phenomenon in which a nuclear spin returns to a steady state, a 90-degree pulse is irradiated after a lapse of time &#x3c4; after finishing applying a 180-degree pulse. An FID signal starts being processed after a lapse of reception delay time Dd after finishing applying the 90-degree pulse. Among the FID signals from protons in a plurality of environments in a solid sample, an FID signal high in time-dependent attenuation rate almost disappears during the lapse of reception delay time Dd. Therefore, an FID signal of a proton in an environment intended to be measured can be easily selected and extracted from FID signals of other protons.

Nuclear magnetic resonance measuring method for solid samples

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Tokushima, Japan

Masahiro Miyake