Jeol Ltd.

Special Reference Laboratories, Inc.

Masahiro Kohno

Makoto Takeuchi

Masaaki Aoyama

Ekuo Yoshida

Mitsuharu Itabashi

Mariko Miura

A method for diagnosis of cancer utilizing an ESR spectrometer comprised a first step for mixing cells from a patient with a solution of hematoporphyrin or hematoporphyrin derivative, a second step for isolating said cells from unreacted reagent and obtaining ESR spectral signal on said cells, a third step for finding quantity S.sub.x of the radicals contained in said cells on the basis of the ESR signal, and a fourth step for comparing value S.sub.x at a predetermined level.

Method for diagnosing cancer using ESR

A spin immunoassay apparatus includes means for sampling one of a plurality of sample solutions, a system for measuring certain amounts of the sample solution, a reaction system for mixing the sample solution with reagent which consists of antibody coupled with spin labelled antigen by antigen-antibody reaction and incubating the mixture for a certain period of time, and an electron spin resonance device for measuring the concentration of a spin labelled material extricated. The electron spin resonance device has a cavity resonator including a fixed cell. A flow system transfers the mixed sample solution and reagent into the cell. The intensity of a magnetic field applied to the cell is adjusted so that the maximum differential value or the minimum differential value of the ESR signal of the spin labelled material will be detected.

Spin immunoassay apparatus

Growing community of inventors

Tokyo, Japan

Masahiro Kohno