Funai Yakuhin Kogyo Kabushiki Kaisha

Nissho Corporation

Kst World Corp.

Funai Kakuhin Kogyo Kabushiki Kaisha

Towa Yakuhin Kabushiki Kaisha

Masahiro Kawasaki

Setsuro Fujii

Naoki Umeda

Bompei Yasui

Tomohisa Miyamoto

Iwao Hashimoto

Kazuko Ando

Mitsuo Nakamura

Yoshio Fukui

Masatoshi Yamato

Mitsuru Hirohashi

Yukio Nakamura

Yuji Mino

Yoneichi Sawai

Masatoshi Shiga

Kenichi Iwamitsu

Yoichiro Kawai

There is provided a method of forming a silicon dioxide film, which comprises repeating a step of depositing a silicon layer on a silicon substrate to form a silicon dioxide film of a predetermined thickness, and which makes it possible to suitably select the surface roughness of the silicon dioxide film that is formed and the rate of growth of the silicon film that is deposited. According to the method of forming the silicon dioxide film that is proposed above, it comprises a step of depositing any one of polysilicon, epitaxial silicon or amorphous silicon on the silicon substrate or on the silicon dioxide film formed on the silicon substrate by the thermal oxidation treatment to form a silicon film, and a step of thermally oxidizing the silicon film to convert it into a silicon dioxide film, the step of deposition and the step of thermal oxidation being repeated a plural number of times.

Method of forming a silicon dioxide film

A pharmaceutical composition for treating inflammatory diseases, comprising (A) an effective amount of hyaluronic acid or its salt, and (B) an effective amount of an anti-inflammatory agent. The composition exhibits a synergistic therapeutic effect on inflammations and is useful for treating inflammatory diseases, particularly diseases of joint with inflammation.

Combined anti-inflammatory agent

Provided herein is a butanediol of the formula: ##STR1## wherein R is an alkyl group containing 5-21 carbon atoms or an alkenyl group containing 5-21 carbon atoms and which contains 1-2 unsaturated bonds. The present invention also contemplates a method of preparing such compounds and the use of such compounds as an anti-tumor agent for treating tumors.

Anti-tumor derivatives of butanediol and process of preparation

2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives possessing strong anti-tumor activity with weak toxicity and represented by the general formula: ##STR1## wherein R stands for an alkyl group, an alkoxy group or a halogen atom, m for zero or an integer of 1-3, and n for an integer of 1-14, with the proviso that when m is 2 or 3, R's may be the same or different and that when m is 2 and the adjacent two R's are alkoxy groups, the two alkyl moieties of the alkoxy groups may be combined to form together with the two adjacent oxa bridging members an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administration.

2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives, a process

New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula ##STR1## wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the proviso that when m is 2, the adjacent two R's may be combined to form an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administration.

Ester derivatives of alkoxybenzoyldeoxyfluorouridine

New ester derivatives of deoxyfluorouridine of the general formula: ##STR1## wherein R and R.sup.40, may be identical or different, and may be hydrogen, halogen or methyl and n is 3 or 4. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administeration.

Ester derivatives of deoxyfluorouridine

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Kashihara, Japan

Masahiro Kawasaki