Eisai Company, Limited

Masahiro Kawahara

Yasuo Miyake

Sumio Watanabe

Takayuki Ohwaki

Naoki Asakawa

Masanori Kayano

Yasuo Ishibashi

Shigeru Sakashita

Ryoichi Machida

Kiyoshi Iwamoto

Yasuharu Saeki

Fumio Sagami

Isamu Hasegawa

Yuichiro Hayashi

Aishin Shinoda

Takeshi Watanabe

An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.

Modified tPA-containing injection composition having increased solubility

A preparation containing a cephalosporin medicament is disclosed. The preparation comprises a cephalosporin derivative represented by the following formula: ##STR1## namely, 7.beta.-{2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetami do}-3-{(E)-3-(carbamoylmethylethylmethylammonio) -1-propen-1-yl}-3-cephem-4-carboxylate or a pharmaceutically acceptable salt thereof salt, lactose, citric acid or a sodium salt thereof, and arginine or a hydrochloride thereof; or the cephalosporin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof, lactose, citric acid or a sodium salt thereof, and sodium chloride.

Injectable preparations containing cephalosporin medicament

A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.

Conjugate of prostaglandin and polysaccharide

A composition containing ubidecarenone, a glycerol mono-fatty acid ester and/or a propylene glycol mono-fatty acid ester, and a liquid oil. Oral administration of the composition provides a promoted absorption of ubidecarenone which is used for improving a coronary function.

Composition containing ubidecarenone with absorption promoted

An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.

Tripamide and cyclodextrin inclusion compound

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Ibaraki, Japan

Masahiro Kawahara