Matsushita Electric Industrial Co., Ltd.

Takeda Pharmaceutical Company Limited

Masahiro Itoh

Hideyuki Okinaka

Atsushi Iga

Tsuneo Yasuma

Yasuo Wakahata

Osamu Ujikawa

Shinji Harada

Hideki Matsukawa

Takeshi Masuyama

Kazuko Aoki

Minoru Hirota

The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein Ris a hydrogen atom or a halogen atom; Ris a group represented by wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof. 

Indole compound

By performing a debinder process before or at the time of firing, and by enhancing a programming rate in the temperature range of 650.degree..about.950.degree. C., the size of particles shows less distribution. Also, when the temperature comprising the particle growth range of 1025.degree..about.1200.degree. C. is maintained for many hours, a zinc oxide varistor having relatively large and uniformly formed particles can be provided. When a zinc oxide varistor compound is fired, a solid solution of zinc oxide spinel is fired at the programming rate of 175.degree. to 500.degree. C./hr in the temperature range comprising the primary phase of from 650.degree. to 950.degree. C., and at the programming rate of 30.degree. to 500.degree. C./hr in the range of from 1250.degree. to 1300.degree. C. Accordingly, a zinc oxide varistor having comparatively large and uniformed formed particles can be obtained. Sintered products obtained in this way show less distribution in operating voltage.

Method of manufacturing zinc oxide sintered compact body

A large number of liquid crystal display devices is formed on a single plane, each of the liquid crystal display devices being formed by arranging liquid crystal between transparent substrates which allow light from a light source to pass through. Display portions of the respective liquid crystal display devices are covered by a masking member (23) and a light guide which is formed of light guide devices, one or more of which being provided for each of said liquid crystal display devices, and junctions between the liquid crystal display devices are also covered by the light guide. With this structure, when the light guides are formed such that the junctions between the plurality of liquid crystal display devices are also covered, lattice-like non-display lines do not appear, thereby providing substantially visually uniform brightness throughout the entire screen of the large-sized liquid crystal display and improving the entire image.

Large-sized liquid crystal display

Growing community of inventors

Osaka, Japan

Masahiro Itoh