School Juridical Person Higashi-nippon-gakuen

Sysmex Corporation

Sekisui Medical Co., Ltd.

Masahiro Ieko

Osamu Kumano

Takeshi Suzuki

Haruki Yamaguchi

Chizuru Morikawa

Naohiko Matsuo

Nobuo Arai

Keiko Hattori

Disclosed is a method for measuring a clotting time, including the steps of:

Method for measuring clotting time, measurement device for clotting time, and reagent kit

The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation.

Method for acquiring information on cause of prolongation of coagulation time, and device

Disclosed is a method for measuring a clotting time, including:

Provided is the development of a convenient LA detection method in which even a sample derived from a patient who receives anticoagulant therapy of warfarin, heparin or the like, is not affected by the anticoagulant therapy, discrimination from the deficiency of blood coagulation factors is enabled, and healthy person's plasma is not used. The method for detecting lupus anticoagulant includes the following steps (A), (B) and (C): (A) a step of adding a buffer solution composition containing blood coagulation factors to each of a blood sample and a diluted sample of the blood sample before measurement or at the time of measurement of the blood coagulation time; (B) a step of measuring the blood coagulation times for the various samples of step (A); and (C) a step of comparing the blood coagulation times for the various samples obtained in step (B).

Method for detecting lupus anticoagulants

Provided is a method of measuring blood coagulation time, the method being capable of LA detection easily and with high sensitivity as compared with the method recommended by the ISTH, without being affected by deficiency of blood coagulation factors even in a blood sample of a warfarin taker, a person who suffers from vitamin K deficiency, or a hepatic failure patient. Disclosed is a method of measuring the blood coagulation time to detect lupus anticoagulant, the method including adding a buffer solution composition containing blood coagulation factors to a blood sample before measurement or at the time of measurement of the blood coagulation time, and measuring the blood coagulation time.

Method of measuring blood coagulation time to detect lupus anticoagulants

Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.

Method, apparatus, and computer program for blood sample determination, and blood sample analyzer

Disclosed is a method for measuring clotting time including: preparing a measurement sample by mixing a blood specimen suspected to contain a lupus anticoagulant, an activator, and a divalent-metal-ion-producing compound for facilitating formation of a phospholipid-containing complex; and measuring a clotting time after adding, to the measurement sample, an aqueous solution of a calcium salt as a coagulation initiator.

Method for measuring clotting time, method for determining presence or absence of lupus anticoagulant, and reagent kit for detecting lupus anticoagulant

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Ishikari-gun, Japan

Masahiro Ieko