Kyowa Hakko Kirin Co., Limited

Masahiro Hoshikawa

Koichiro Nishimura

Iwao Chujo

Takashi Mimura

Shuji Ishihara

Tsutomu Matsumura

Koji Hagihara

Provided are a method for purifying mitomycin C, comprising a step of recrystallizing crude mitomycin C crystals using a high-purity methanol; mitomycin C obtainable by the method; and the like.

Method for purifying mitomycin C

The present invention provides a method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV): [wherein X represents halogen, OSOR(wherein Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or OC(&#x2550;O)R(wherein Rhas the same meaning as the above R), or the like, and R, Rand Rmay be the same or different and each represents substituted or unsubstituted aryl or the like] or a salt thereof, which comprises reacting a compound represented by Formula (I): a compound represented by Formula (II):H&#x2014;X&#x2003;&#x2003;(II)(wherein X has the same meaning as defined above), and a compound represented by Formula (III): (wherein R, Rand Rhave the same meanings as defined above, respectively), and the like.

Method for producing indazol-3-ylmethyl phosphonium salt

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Tokyo, Japan

Masahiro Hoshikawa