Kyushu University

Sumitomo Metal Mining Company, Ltd.

Nissan Chemical Industries Limited

Japan Science and Technology Agency

Kobayashi Pharmaceutical Co., Ltd.

Chanel Parfums Beaute

Denso Corporation

Nippon Soken, Inc.

Nissan Chemical Corporation

Masahiro Goto

Fukiko Kubota

Yuzo Baba

Takehisa Iwama

Nobuhide Miyachi

Takayuki Imoto

Yoshitomo Ozaki

Keigo Matsumoto

Satoshi Asano

Tatsuya Higaki

Takeo Tsuzuki

Ikuo Hayashi

Hiroyuki Kani

Masatoshi Takano

Misao Miyamoto

Tsubasa Kashino

Noriho Kamiya

Masayoshi Miyamoto

Toshihiko Nagakura

Shinya Matsumoto

Jiro Hayata

Takahiro Nakata

Junji Akaki

Yoshiro Tahara

Hirofumi Ichinose

Momoko Kitaoka

Nobuko Okamura

Yoshihito Oda

A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein Ris a Caliphatic group; Ris a hydrogen atom or a Calkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; Ris a &#x2014;(CH)&#x2014;X group; n is a number of 1 to 4; and X is amino group, guanidino group, &#x2014;CONHgroup, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.

Transdermally absorbable base material containing lipid peptide compound

A method for producing a nonaqueous composition for external use on the skin including a strongly hydrophilic amphiphilic solid active ingredient-surfactant complex dissolved or dispersed in an oil phase, the method including the steps of: dissolving a surfactant in an oil phase to obtain a surfactant solution; mixing the obtained surfactant solution with a strongly hydrophilic amphiphilic solid active ingredient to obtain a suspension; and allowing the obtained suspension to stand still to obtain a transparent composition. Unlike conventional methods for preparing S/O formulations, the strongly hydrophilic amphiphilic solid active ingredient can be solubilized in an oil phase without the process of emulsification and freeze drying.

Method for producing nonaqueous composition for external use on skin

An object of the present invention is to provide a composition for external use having excellent percutaneous absorption properties. A composition for external use comprising a water-soluble fraction dispersed in an oily phase, wherein the water-soluble fraction contains a surfactant and a solution in which a water-soluble substance is dissolved in water, and the content of the water in the water-soluble fraction is 0.1 to 2.5% by weight based on the composition for external use.

Composition for external application

Provided are: an extractant which is capable of quickly and highly efficiently extracting zirconium from an acidic solution that is obtained by acid leaching a material containing zirconium and scandium such as an SOFC electrode material; and a method for extracting zirconium, which uses this extractant. A zirconium extractant according to the present invention is composed of an amide derivative represented by general formula (I). In the formula, R1 and R2 respectively represent the same or different alkyl groups, each of which may be linear or branched; R3 represents a hydrogen atom or an alkyl group; and R4 represents a hydrogen atom or an arbitrary group other than an amino group, said arbitrary group being bonded, as an amino acid, to the &#x3b1; carbon.

Zirconium extractant and method for extracting zirconium

Provided is a system for efficiently recovering trace metal from a large amount of a raw material, such as when trace metal is recovered from nickel oxide ore. This ion exchange resin has, on a carrier, an amide derivative represented by the following general formula. In the formula, R1 and R2 represent the same or different alkyl groups, R3 represents a hydrogen atom or an alkyl group, and R4 represents a hydrogen atom or an arbitrary group, other than an amino group, bonded to &#x3b1; carbon as an amino acid. The amide derivative is preferably a glycinamide derivative. The carrier preferably includes a primary amine and/or a secondary amine.

Ion exchange resin and method for adsorbing and separating metal

Provided are an extraction agent and extraction method that selectively extract and, at a low cost, recover gallium from an acidic solution containing gallium and zinc. The gallium extraction agent comprises an amide derivative represented by general formula (I). In the formula, Rand Reach indicate the same or different alkyl group, Rindicates a hydrogen atom or an alkyl group, and Rindicates a hydrogen atom or any given group, other than an amino group, bonded to the &#x3b1;-carbon as an amino acid. The general formula preferably has a glycine unit, a histidine unit, a lysine unit, an aspartic acid unit, or an N-methylglycine unit. By extracting gallium from an acidic solution containing gallium and zinc by means of solvent extraction using the extraction agent, it is possible to selectively extract gallium.

Gallium extraction agent and gallium extraction method

In the present invention, nickel is selectively extracted from an acidic solution that contains a high concentration of manganese. This valuable metal extraction agent is represented by the general formula. In the formula, Rand Rare alkyl groups that may be the same or different, Ris a hydrogen atom or an alkyl group, and Ris a hydrogen atom or any group, other than an amino group, bonded to an &#x3b1; carbon atom of an amino acid. The general formula preferably has a glycine unit, a histidine unit, a lysine unit, an aspartic acid unit or a n-methylglycine unit. When extracting nickel by using this extraction agent, it is preferable to adjust the pH of the acidic solution to 2.3 to 5.5 inclusive.

Nickel extraction method

It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1): (where Rto Rare independently an organic group) or a pharmaceutically usable salt thereof.

Cosmetic, external skin preparation, and medical instrument

In order to selectively extract copper and/or lead from an acidic solution containing high concentrations of manganese, etc., the valuable-metal extracting agent of the present invention is expressed by general formula (1). In the formula, Rand Reach represent the same or different alkyl groups, Rrepresents a hydrogen atom or an alkyl group, and Rrepresents a hydrogen atom or a given group, other than an amino group, that bonds with an &#x3b1; carbon as an amino acid. In general formula (1), the inclusion of a glycine unit, a histidine unit, a lysine unit, an asparagine acid unit, or a normal methylglycine unit is preferred. When using the extracting agent to extract copper/and lead, it is preferable that the pH of the acidic solution be adjusted to 1.0-5.5 inclusive. 

Valuable-metal extraction method

There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.

Gel sheet containing lipid peptide gelator and polymeric compound

Provided is a method for selectively extracting and inexpensively recovering scandium from an acidic solution containing calcium, magnesium, and scandium. The scandium extraction method according to the present invention involves subjecting an acidic solution containing calcium, magnesium, and scandium to solvent extraction using an extraction agent consisting of an amide derivative represented by the general formula below. In the formula, Rand Rrepresent the same or different alkyl groups, and Ris a hydrogen atom or alkyl group. The amide derivative preferably consisting of one or more derivatives selected from glycine amide derivatives, histidine amide derivatives, lysine amide derivatives, and aspartic acid amide derivatives. The pH of the acidic solution is preferably pre-adjusted to between 1 and 4. 

Scandium extraction method

Provided is a method for efficiently separating nickel, cobalt and/or scandium, and impurities from an acidic solution containing impurities such as manganese, iron, zinc, and aluminum. A valuable-metal extracting agent of the present invention is expressed by general formula (1). In the formula, Rand Reach represent the same or different alkyl groups, Rrepresents a hydrogen atom or an alkyl group, and Rrepresents a hydrogen atom or a given group, other than an amino group, that bonds with an &#x3b1; carbon as an amino acid. In general formula (1), the inclusion of a glycine unit, a histidine unit, a lysine unit, an asparagine acid unit, or a normal methylglycine unit is preferred. 

Method for separating impurities from an acidic solution containing nickel and cobalt and/or scandium

The present invention extracts precious metals from an acidic solution containing precious metals in an early and highly efficient manner. Provided is an extraction agent for precious metals that is represented by the general formula below. In the formula, R1 and R2 each represent the same alkyl group or different alkyl groups, R3 represents a hydrogen atom or an alkyl group, and R4 represents a hydrogen atom or a discretionary group that is not an amino group and that bonds to &#x3b1; carbon as an amino acid. By subjecting an acidic solution containing precious metals to solvent extraction using the extraction agent for precious metals, a plurality of precious metals can be recovered all at once from a solution containing a large amount of various impurities. 

Extraction agent for precious metals and rhenium, and extraction method for precious metals and rhenium using same

To efficiently and selectively recover scandium from an acid solution containing calcium, magnesium and scandium. In the present invention, an acid solution containing calcium, magnesium and scandium is brought into contact with a scandium recovering resin impregnated with an amide derivative represented by the following general formula for an hour or more. In the formula, Rand Reach represent the same or different alkyl groups. The alkyl group can be a straight chain or a branched chain. Rrepresents a hydrogen atom or an alkyl group. Rrepresents a hydrogen atom or any group other than an amino group, which is bound to the &#x3b1; carbon as an amino acid. The amide derivative is preferably any one or more of glycinamide derivatives, histidinamide derivatives, lysinamide derivatives and aspartic acid amide derivatives. 

Growing community of inventors

Fukuoka, Japan

Masahiro Goto