Fuso Pharmaceutical Industries, Ltd.

Osaka Prefecture University

Other

Osaka Nanko Zoki Japan, Ltd.

Tachibana-Technos Co., Ltd.

Masahiro Asakura

Shinji Yamasaki

Hirotsugu Uehara

Kanako Abe

Worada Samosorunsuk

Yuichi Oku

Souji Eda

Yoshihiko Uesaka

Kazumasa Nishida

Norihiko Sugimoto

Kazumasa Kamei

Yusuke Shibahara

Aya Keshi

Nana Sakamoto

Shiho Yamazaki

Atsushi Hinenoya

Iwao Morikochi

Mamoru Yamaguchi

Yukitoshi Sakuramoto

Toshiyuki Nishino

A sheet heater () includes: a heat-insulating base material (); a metal-coated base material () arranged on the heat-insulating base material; a cord-like heating element () arranged on a side closer to the metal-coated base material with respect to the heat-insulating base material; and a black thermal fusion layer () arranged adjacent to the cord-like heating element.

Sheet heater

Very simple, highly sensitive detection or quantification of target nucleic acids of interest has been achieved by: hybridizing mask oligonucleotides to regions in a single-stranded region of a nucleic acid to be assayed between which a region to be hybridized by an oligonucleotide probe is positioned, thereby opening the probe-hybridizing region and keeping the single-stranded region of the target nucleic acid stable, and then subjecting this nucleic acid having the single-stranded region to nucleic acid chromatography.

Nucleic acid detection or quantification method using mask oligonucleotide, and device for same

The present invention provides antibodies that show specific reactivity to disulfide-type HMGB1. Furthermore, the present invention provides methods for specifically measuring disulfide-type HMGB1 using the antibodies, and kits or reagents for the measurement. The present invention also provides methods for measuring total HMGB1 using such an antibody and an antibody that binds to both disulfide-type HMGB1 and reduced-type HMGB1 but does not bind to des-HMGB1, and kits or reagents for the measurement.

Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement

The present invention has demonstrated that microorganisms present in a liver can be killed by washing the bile duct and the portal vein with hot water, and then disinfecting the liver using a chlorine-based disinfectant. It has also been demonstrated that sterilizing effects can be enhanced by freezing the liver after disinfection with a chlorine-based disinfectant.

Method for producing disinfected liver

An objective of the present invention is to provide the cytolethal distending toxin (CDT) ofand polynucleotides encoding it, and novel methods for detection ofusing the cdt genes. The present inventors focused on the cytolethal distending toxin (CDT) ofbacteria, and detected the cdt genes of a-like bacterium isolated from an enteritis patient in Thailand. The present inventors discovered a bacterial strain whose cdtB gene was amplified by common primers in, and, but not by multiplex PCR that can specifically detect the cdtA, cdtB, and cdtC genes of the three bacterial species. The bacterial strain was identified asby 16S rRNA gene analysis. Furthermore, the entire nucleotide sequence of the cdt genes was determined by genome walking upstream and downstream of the cdtB gene.

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The present inventors succeeded in cloning the CDT genes ofand, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs ofand. Furthermore, the inventors demonstrated that these primers were applicable to multiplex PCR that simultaneously allows for the rapid and convenient determination of the presence ofCDT and identification of species, and that they can also be used in PCR-RFLP-based typing.

Cytolethal distending toxins and detection of campylobacter bacteria using the same as a target

Growing community of inventors

Osaka, Japan

Masahiro Asakura