Takeda Chemical Industries, Inc.

Masahiko Yoneda

Toru Hasegawa

Satoshi Horii

Ikuo Nogami

Muneharu Doi

Yukimasa Nozaki

Akira Imada

Yoshio Nakao

Ken-ichi Sasajima

Teruo Fukuhara

Akira Yokota

This invention provides a method for producing Antibiotic T-42082 wherein the method comprises cultivating an Antibiotic T-42082-producing strain of the genus Streptomyces (ATCC 31080) to permit said strain to elaborate and accumulate Antibiotic T-42082 in the resultant broth and harvesting the antibiotic from said broth. This invention also includes the novel antibiotic.

Method for producing antibiotic T-42082 and antibiotic T-42082

D-Ribose is produced by cultivating a strain belonging to the genus Bacillus, which lacks sporulation ability or has high 2-deoxy-D-glucose-oxidizing activity or has both of these two properties and also lacks at least one of transketolase and D-ribulose phosphate 3-epimerase, to cause said strain to elaborate and accumulate a large amount of D-ribose. The thus accumulated D-ribose can be recovered in good yield.

Method for the production of D-ribose

A novel aminoglycoside antibiotic, xylostasin, of the nomenclature O-.beta.-D-xylofuranosyl-(1.fwdarw.5)-O-[.alpha.-2,6-diamino-2,6-dideoxy-D -glucopyranosyl-(1.fwdarw.4)]-2-deoxystreptamine and its pharmaceutically acceptable acid salts which are effective against infections with bacteria, and a process for producing the antibiotic by cultivating a strain belonging to the genus Bacillus which is capable of producing the antibiotic.

Process for the preparation of xylostasin

Growing community of inventors

Kobe, Japan

Masahiko Yoneda