Panasonic Corporation

Matsushita Electric Industrial Co., Ltd.

Panasonic Intellectual Property Management Co., Ltd.

Imec Vzw

Katholieke Universiteit Leuven, Ku Leuven R&d

Imec

Matsushita Electrical Industrial Co., Ltd.

Katholieke Universiteit Leuven

Masahiko Shioi

Tatsurou Kawamura

Masaru Minamiguchi

Shinji Uchida

Yasuaki Okumura

Kiyoko Oshima

Pol Van Dorpe

Atsushi Matsubara

Kristof Lodewijks

Hilde Jans

Liesbet Lagae

Kazuaki Nishio

Hiroto Yanagawa

Emina Ikeuchi

Karolien Jans

Takahiro Aoki

Osamu Akasaka

Noriaki Fukumoto

Jian Ye

A pathogen detection system includes pathogen detectors disposed in different locations, and a controller. The pathogen detectors include a first pathogen detector and a second pathogen detector. The first pathogen detector transmits a first detection result obtained as a result of pathogen detection to the controller, and the second pathogen detector transmits a second detection result obtained as a result of pathogen detection to the controller. In a case where the first detection result satisfies a predetermined condition, the controller causes the second pathogen detector to change a mode related to the pathogen detection from a first mode to a second mode.

Pathogen detection system and pathogen detection method

The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.

Detection device and detection method

A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.

Sensor embedding device and sensor embedding system

An exemplary sensor chip includes a substrate, a metal pattern formed on a side of the substrate that is irradiated with excitation light, and a first substance and a second substance provided near the metal pattern. A first intensity Xa of the first surface-enhanced Raman-scattered light from the first substance and a second intensity Xb of the second surface-enhanced Raman-scattered light from the second substance are detected. An intensity ratio Xc, as obtained by dividing the second intensity Xb with the first intensity Xa, is calculated.

Method and detection system for detecting an analyte

A method () for determining a concentration of an analyte in a fluid or fluid sample, comprises: providing () a SERS substrate comprising receptor molecules () capable of binding competitor molecules (); contacting () the SERS substrate () with a fluid (sample) comprising analyte () and such competitor molecules (); radiating () the SERS substrate () with a light source while measuring a SERS signal; and determining () a concentration of the analyte () based on the measured signal level. A corresponding device and system are also provided.

Method and device for detecting analytes

An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.

Method and apparatus for measuring concentration of test substance in organism

An exemplary sensor chip includes a substrate, a metal pattern, a proximate substance, and a light shielding layer. The metal pattern is on the substrate. The proximate substance is on or near the metal pattern. The light shielding layer is provided on the substrate so as to cover the metal pattern and the proximate substance. The light shielding layer is a layer that blocks the excitation light from going into the proximate substance, and is made of a substance which becomes degraded inside a subject.

Sensor chip, detection method, and detection apparatus

A method for measuring a concentration of a biogenic substance in a living body includes steps of: preparing an apparatus including a light source, a substrate which has periodic metal structures and generates surface enhanced Raman scattering light by being irradiated with light from the light source, and spectroscopic means which disperses and detects the light, wherein the periodic metal structure is arranged with first and second distances in first and second direction respectively, the first distance is set to generate surface plasmon by matching a phase of the light from the light source, and the second distance is smaller than the first distance and is set between 300 nm and 350 nm; irradiating the substrate with the light from the light source to generate the surface enhanced Raman scattering; detecting the scattering with the spectroscopic means; and calculating the concentration of the biogenic substance based on the scattering.

Method and apparatus for measuring concentration of biogenic substance

A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer The substrate further comprises at least one nanoparticle comprising an electrically conductive portion. The electrically conductive portion may provide an opening to an underlying material. Such at least one nanoparticles may be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate further comprises a dielectric spacer for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer is a dielectric material substantially only present under the at least one nanoparticle, leaving the electrically conductive layer uncovered from dielectric material at positions away from the nanoparticles. The at least one nanoparticle and the dielectric spacer are interfaced along a first major surface and the at least one nanoparticle comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer.

Surface enhanced optical detection substrate for sensing purposes and methods for manufacturing

A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.

Method for measuring concentration of antigen contained in test solution

One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.

Method for measuring a concentration of a biogenic substance contained in a living body

The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation:()=Am &#xb7;sin(&#x3c9;)+, where(): received signal, Am: amplitude,: time,: a constant number, and &#x3c9;: angular speed.

One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.

The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.

Method and apparatus for biogenic substance concentration measurement

A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided. The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.

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Kyoto, Japan

Masahiko Shioi