Api Corporation

Other

Masahiko Seki

Takeshi Sakai

Yuji Kuroda

Hiroyuki Nakazumi

Shozo Suefuku

Mitsuto Montani

Yumiko Fujita

The invention provides a production method of a biaryl compound of the formula [3] or a salt thereof, including reacting a 2-phenylazole derivative of the formula [1] or a salt thereof, with a benzene derivative of the formula [2] or a salt thereof in the presence of a metal catalyst, a base, and one or more of (a) a monocarboxylic acid metal salt, (b) a dicarboxylic acid metal salt, (c) a sulfonic acid metal salt, and (d) a phosphate or phosphoric amide metal salt represented by RP(O)(OM) wherein each symbol is as defined herein.

Method for producing biaryl compound

The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers. Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Br&#xf8;nsted acid: wherein each symbol is as defined in the present specification.

Deprotection method for tetrazole compound

Microcapsules containing a radiation sensitive composition and their use

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Tokyo, Japan

Masahiko Seki