Ube Industries, Inc.

Daiichi Sankyo Company, Limited

Santen Pharmaceutical Co., Ltd.

Other

Kurume University

University of Tsukuba

Ube Corporation

Santen Pharmaceuticalco., Ltd.

Masahiko Hagihara

Yukinori Wada

Motohisa Shimizu

Ken-ichi Komori

Kazutaka Kido

Hiroshi Nishida

Hidetoshi Sunamoto

Takeshi Matsugi

Yasunori Tsuzaki

Noriaki Iwase

Nobuhiko Shibakawa

Tadashi Nakajima

Masakazu Hatano

Hideaki Hara

Masayuki Tanaka

Hiroyuki Miyata

Tetsushi Katsube

Tetsuo Kawaguchi

Eiji Okanari

Kenji Yoneda

Keiichi Ito

Kikuo Ataka

Teruhiko Inoue

Hiroshi Fujiwara

Katsunori Takata

Keiji Matsunobu

Tsuyoshi Nakamura

Yasuhito Yamamoto

Hidenori Namiki

Haruo Iwabuchi

Yoshiaki Kuroki

Masayoshi Oue

Atsushi Shimazaki

Yasuhiro Aga

Makoto Okudo

Koji Ito

Naoyuki Yokota

Yasunori Tokunaga

Katsuhiro Kobayashi

Naoki Terasaka

Ryo Iwamura

Keisuke Ohta

Manabu Shigetomi

Osamu Kikuchi

Tomokazu Fujimoto

Shingo Hirashima

Naoto Suzuki

Akira Takama

Takahiro Motoyama

Hitoshi Ueno

Tomoko Kanda

Hiroyuki Setoguchi

Kousuke Baba

Nobuya Satake

Kimihiko Yoshimura

Ichiro Tanaka

Masamichi Nishihara

Toshiyuki Shirai

Tohru Hasegawa

Shinsaku Fuse

Akiyoshi Fukamizu

Jun-Dal Kim

Yukinori Kawai

Akiko Shima

Kazunari Tsuboike

Gen Mizuno

Takayuki Nakanishi

Masao Maruyama

Kenichi Arai

Nobuyoshi Fujii

Kazuyoshi Nakamura

Ken-Ichi Komori

Yoko Murakami

Yasushi Yoshigae

The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.

Cell cultivation module

The present invention relates to a cell culturing method and kit. More specifically, it relates to a cell culturing method and kit using a support that is exposed to the air. It further relates to a method of culturing cells by allowing them to migrate onto a porous polyimide film.

Cell culturing method and kit

The present invention pertains to a method for the mass cultivation of cells, and a cell cultivation device and kit. The present invention further pertains to a continuous cell cultivation method and a continuous cell cultivation device in which a carrier is used.

Method, device and kit for mass cultivation of cells using polyimide porous membrane

The purpose of the present invention is to provide a method for isolating, removing and analyzing cells. Provided is a method for isolating, removing and analyzing cells by filtering a liquid specimen containing cells through a porous polyimide film, and subjecting the cells captured by the film which did not pass through the porous polyimide film, or the cells in the liquid specimen which did pass through the porous polyimide film, to an examination of one or more cell properties selected from a group consisting of cell number or type, internal or external cell structure, type or amount of cell surface antigen, type or amount of material secreted from cells, cell adhesion, and cell survival rate.

Method for isolating, removing and analyzing cells

The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further relates to a cell cryopreservation method and kit employing the porous polyimide film.

Long-term cell-cultivation using polyimide porous membrane and cell-cryopreservation method using polyimide porous membrane

The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.

Cell culture method using bone marrow-like structure, and porous polyimide film for healing bone injury site

The present invention provides: a method for producing a mixed sulfonic acid anhydride of the general formula (1) by reacting a sulfonic acid compound of the general formula (2) with a perfluoroalkyl sulfonic acid anhydride or a perfluoroalkyl sulfonic acid halide; and a method for producing a sulfonamide compound of the general formula (4) obtained by reacting an amine compound of the general formula (3) with a mixed sulfonic acid anhydride of the general formula (1).

Method for producing heteroaromatic sulfonamide compound

The present invention relates to a method of using cells to produce a substance, and involves applying the cells to a polyimide porous film, culturing the cells and producing the substance by means of the cells.

Method of producing substance

The present invention relates to a cell culturing method and cell culturing apparatus and kit for use therewith. The method includes applying cells on a porous polyimide film and culturing. One embodiment includes a process for sowing cells on the surface of the film. Another embodiment includes a process for placing a cell suspension on the dried surface of the film and leaving the film undisturbed, moving the film to promote liquid efflux, or stimulating a portion of the surface to entangle the cell suspension into the film, and then retaining the cells in suspension inside the film while allowing moisture to flow out. Another embodiment includes a process for moistening one or both surfaces of the film with a cell culture solution or sterilized liquid, loading a cell suspension on the moistened film, retaining the cells in suspension inside the film, and allowing moisture to flow out.

Cell culturing method, cell culturing apparatus and kit comprising a porous polyimide film

The present invention provides a salt of a substituted pyridine compound which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a salt of a compound represented by general formula (I): wherein Ris optionally substituted alkoxy or the like.

Acid addition salt of substituted pyridine compound

The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein Ris H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.

Substituted pyridine compound

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Ube, Japan

Masahiko Hagihara