Kureha Kagaku Kogyo Kabushiki Kaisha

Nippon Oil Fats Co., Ltd.

Kureha Chemical Industry Company, Limited

Fuji Latex Co., Ltd.

Masahiko Fujii

Chikao Yoshikumi

Takayoshi Fujii

Koichi Niimura

Takao Ando

Takao Furusho

Kenichi Matsunaga

Shigeaki Muto

Yoshiharu Oguchi

Akira Kobayashi

Kenichi Saito

Akihiko Kanno

Akinori Suginaka

Kouichi Niimura

Shinichi Akimoto

Mitsuo Mizuno

Naoki Yamamoto

Minoru Ohara

Toshihiko Wada

Haruhisa Hayashi

Hiromitsu Makita

Kinzaburo Suzuki

Yutaka Enomoto

Akio Shinmyo

Tsuneo Akatsu

A condom prophylactic against AIDS infection coated with acidic polysaccharides is provided which has an antiviral action and a method of the manufacture thereof. The acidic polysaccharides can be polysaccharides, protein-bound saccharides and glycolipids such as extracts from sea-weeds, extracts from Procaryomycota and Eucaryomycota, carrageenan and so on which have acidic groups such as sulfuric acid group in a portion of polysaccharides. A condom is coated with a solution of said acidic polysaccharides, and optionally with a lubricant. AIDS infection can be prevented without side effect by using a condom of the present invention.

Condom coated with acidic polysaccharides

A composition comprising as an active ingredient a compound consisting of an immunoglobulin F.sub.c fragment and an alkylating, antibiotic, or antimetabolic antitumor substance bound thereto, and a pharmaceutically acceptable carrier is disclosed. The Fc fragment moiety in the compound is stable in a living body, and thus the activity of the antitumor substance therein is maintained over a long period.

Immunoglobulin F.sub.c fragment bound to an alkylating, antibiotic, or

Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.

Anti-tumor substance and process for producing the same

Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives

Anti-tumor substance of immunoglobulin and melphalan and process for

Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).

Derivative of cephalosporanic acid and pharmaceutical composition

Polysaccharides having antitumor and other useful pharmacological activities and a process for preparing such polysaccharides are disclosed. These polysaccharides are characterized by .alpha.-bonding of the saccharide component and can be produced from the extracts obtained by the extraction of a basidiomycetous fungus belonging to the genus Coriolus or cultures thereof with an aqueous solvent.

Polysaccharides pharmaceutical compositions and the use thereof

The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.

Platinum compound and drug

A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

Suppository base composition

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 atoms or an alkali metal and R is --CH.sub.2 COOR', --CH.sub.2 CH.sub.2 SR', ##STR2## or --CH.sub.2 CH.sub.2 COOR' wherein R' is defined above. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Cephalosporin derivative and pharmaceutical composition containing the

A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkali metal. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the purification of the antibody to tumor (cancer) antigen via affinity-chromatography and an antitumor substance (anti-cancer drug).

Pharmaceutical composition having antitumor activity

Platinum compound

Molded, storage stable suppository base composition of specified amounts

Disclosed is a novel pharmaceutical composition having antitumor activity without causing pyrexia and anaphylaxis formed by an amido bonding between an antibody obtained by the purification of the antibody to tumor antigen via affinity-chromatography and an antitumor substance.

Growing community of inventors

Tokyo, Japan

Masahiko Fujii