Teijin Limited

Merck + Co., Inc.

Teijin Pharma Limited

Masahiko Dohi

Yuji Makino

Yasuhide Uejima

Yoshihisa Nishibe

Takao Fujii

Seiji Mochizuki

Hideo Matsugi

Tako Fujii

Yasuhiro Zaima

Takao Hujii

Yoshiki Suzuki

Hiroshi Kuroda

Michio Iwai

Hiroko Mochizuki

Akemi Kitada

Kazuhiro Nakamura

A powdery composition for nasal administration, where (1) the composition contains (i) a drug, (ii) a water-absorbing and gel-forming base material such as hydroxypropyl cellulose or hydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insoluble base material such as crystalline cellulose or &#x3b1;-cellulose, (2) wherein the amount of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and gel-forming base material and the water-absorbing and water-insoluble base material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbing and water-insoluble base material than on/in the water-absorbing and gel-forming base material.

Powdery composition for nasal administration

A powdery composition for nasal administration, where

Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter () in a filter-fitting portion () of a container (), inserting an inner cylinder () in the container body (), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure () to the container and to the inner cylinder, fitting a nozzle () to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly.

Method of producing powered medicine multi-dose administering device and apparatus thereof

There are provided a solid preparation containing a single crystal of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, an excipient and a disintegrating agent, and a method for producing the same.

Solid preparation containing single crystal form

A method of weighing an easily chargeable measured object able to remove the effects of static electricity to weigh a measured object by an accuracy of about 0.3 mg continuously with a good work efficiency. When using an electronic scale () provided with a weighing platform () and a weighing pan () able to move vertically by a very small distance with respect to the weighing platform to weight an easily chargeable measured object (), the measured object is weighed in the state with a conductive frame () of a suitable size set on the weighing platform () around the weighing pan so as to surround the measured object placed on the weighing pan.

Method and apparatus for weighing easily chargeable measured object

There is provided a powder composition for nasal administration comprising a drug having a particle size of less than 10 &mgr;m or a lyophilized drug, a water-absorbing and water-slightly soluble base material, and a water-absorbing and gel-forming base materials. The composition has excellent drug absorbability.

Powder Composition for nasal administration

A powdered medicine multi-dose administering device in which a hole ( ) is formed in the bottom surface of a medicine storage chamber ( ) capable of storing a powdered medicine of an amount of many times of administering operation, the hole ( ) being located at a position where a pump unit can be communicated with the exterior via a pipe ( ). At the administering position, the powdered medicine in a medicine container unit ( ) is injected out of the device together with the air through the pipe, while the hole is kept away from being brought into contact with opening means ( ).

Powdered medicine multi-dose administering device

A powdered medicine multi-dose administering device has a medicine container unit ( ) for containing a unit-dose of medicine under the lower surface of the medicine storage chamber ( ) storing the medicine in a multi-dose amount. A medicine guiding unit ( ) moves between a filling position and an administering position while maintaining a contact with the bottom surface. At the filling position, the medicine container unit is opened to the medicine storage chamber and is filled with the medicine. As the medicine container unit moves from the filling position to the administering position, the powdered medicine in the medicine container unit is swept and metered. At the administering position, the medicine in the medicine container unit is injected by the action of the pump unit ( ) through a filter ( ) and a pipe ( ).

Device for feeding a powder in a predetermined amount and method thereof

A powdery nasal composition comprising a drug and colloidal cellulose is provided. The composition is a nasal composition providing a superior absorption activity for the drug.

Powdery nasal compositions

Container with dispensing means

The object of the present invention is to provide a preparation for local administration to permit selective delivery of an effective amount of sodium alendronate to the bone site where bone resorption is accentuated.

Sodium alendronate preparation for local administration

The present invention provides a method local administration of an effective amount of sodium alendronate to permit selective delivery to the bone site where bone resorption is accentuated.

Growing community of inventors

Tokyo, Japan

Masahiko Dohi