Kao Corporation

Masahide Hoshino

Yoshiya Sugai

Hiroaki Saito

Yoshinori Nishizawa

Yasushi Katayama

Mituru Sugiyama

Hiroshi Kusuoku

Akiyo Kameyama

Yutaka Takagi

Akira Kawamata

Genji Imokawa

Akira Yamamuro

Ichiro Tokimitsu

Minoru Nagai

Tadashi Hase

Koji Yoshino

Mitsuru Sugiyama

Koichi Murayama

Youichi Arai

Hiroko Joukura

Atsuko Otsuka

Shinichi Meguro

Kiyoko Sugino

The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, Rand Rare the same or different and each represents a Chydrocarbon group, Rand Rare the same or different and each represents a divalent Chydrocarbon group, Rs are the same or different and each represents a divalent Chydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Composition for external application

The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, Rrepresents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, Rrepresents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and Rrepresents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

Dermatological preparations

External preparation compositions

Amide derivatives and external skin or hair care preparations

An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.

Amide derivatives and their use in cosmetic composition

The invention relates to UV absorbers and cosmetic compositions containing a naphthalenemethylenemalonic diester represented by the following formula (1): ##STR1## wherein NAP represents a naphthalene group which may optionally have a substituent, and R.sup.1 and R.sup.2 each independently represent a hydrocarbon group, an alkoxyalkyl group, or an alkoxyalkylenoxyalkyl group. The UV absorbers and the cosmetic compositions of the invention exhibit excellent ultraviolet ray absorbing action, and are stable to light.

Naphthalenemethylenemalonic diesters, and UV absorbers and cosmetic

Growing community of inventors

Haga-gun, Japan

Masahide Hoshino